PMID- 23397239
OWN - NLM
STAT- MEDLINE
DCOM- 20140328
LR  - 20211021
IS  - 1861-0293 (Electronic)
IS  - 1340-3443 (Linking)
VI  - 67
IP  - 4
DP  - 2013 Oct
TI  - Screening of promising chemotherapeutic candidates from plants against human 
      adult T-cell leukemia/lymphoma (III).
PG  - 894-903
LID - 10.1007/s11418-013-0747-2 [doi]
AB  - Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature peripheral T 
      lymphocytes caused by human T-cell lymphotropic virus type I (HTLV-I). In our 
      previous paper, 214 extracts from 162 plants were screened to elucidate the 
      anti-proliferative principles against HTLV-I-infected T-cell lines. In this 
      study, 245 extracts from 182 plants belonging to 61 families were further tested 
      against two HTLV-I-infected T-cell lines (MT-1 and MT-2). Potent 
      anti-proliferative effects were exhibited against MT-1 and MT-2 cells by 52 and 
      60 of the 245 extracts tested, respectively. Of these, two extracts showed strong 
      inhibitory activity (EC(5)(0) values 0.1-1 mug/mL; +++) against both cells, 7 extracts 
      showed moderate inhibitory activity (EC5(5)(0) values 1-10 mug/mL; ++), and 43 
      extracts showed weak inhibitory activity (EC(5)(0) values 10-100 mug/mL; +), whereas 
      the remaining extracts did not show any activity (EC(5)(0) values >100 mug/mL; -) 
      against MT-1 cells. On the other hand, 10 extracts showed moderate inhibitory 
      activit and, 48 extracts showed weak inhibitory activity, whereas the remaining 
      extracts did not show any activity against MT-2 cells. Extracts from the aerial 
      parts of Annona reticulata and A. squamosa showed the most potent inhibitory 
      activity and three aporphine alkaloids were isolated from their extracts as the 
      active principles by activity-guided fractionation.
FAU - Nakano, Daisuke
AU  - Nakano D
AD  - Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
FAU - Ishitsuka, Kenji
AU  - Ishitsuka K
FAU - Kamikawa, Mio
AU  - Kamikawa M
FAU - Matsuda, Michika
AU  - Matsuda M
FAU - Tsuchihashi, Ryota
AU  - Tsuchihashi R
FAU - Okawa, Masafumi
AU  - Okawa M
FAU - Okabe, Hikaru
AU  - Okabe H
FAU - Tamura, Kazuo
AU  - Tamura K
FAU - Kinjo, Junei
AU  - Kinjo J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130210
PL  - Japan
TA  - J Nat Med
JT  - Journal of natural medicines
JID - 101518405
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Adult
MH  - Annona/chemistry
MH  - Antineoplastic Agents, Phytogenic/chemistry/*therapeutic use
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Human T-lymphotropic virus 1
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/*drug therapy/virology
MH  - Plant Extracts/chemistry/therapeutic use
EDAT- 2013/02/12 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/02/12 06:00
PHST- 2012/09/12 00:00 [received]
PHST- 2013/01/18 00:00 [accepted]
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - 10.1007/s11418-013-0747-2 [doi]
PST - ppublish
SO  - J Nat Med. 2013 Oct;67(4):894-903. doi: 10.1007/s11418-013-0747-2. Epub 2013 Feb 
      10.