PMID- 23398428
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20190104
IS  - 1466-1799 (Electronic)
IS  - 0007-1668 (Linking)
VI  - 53
IP  - 6
DP  - 2012
TI  - Chromium histidinate protects against heat stress by modulating the expression of 
      hepatic nuclear transcription factors in quail.
PG  - 828-35
LID - 10.1080/00071668.2012.747084 [doi]
AB  - 1. This experiment was conducted to evaluate the effects of supplemental chromium 
      histidinate (CrHis) on performance and expressions of hepatic nuclear factors 
      kappaB, an enhancer (NF-kappaB) and an inhibitor (IkappaBalpha) of activated B cells in 
      heat-stressed Japanese quail (Coturnix coturnix japonica). 2. A total of 180, 
      10-d-old Japanese quail were allocated randomly into 6 groups in a 2 x 3 
      factorial arrangement. Birds were reared either at 22 degrees C for 24 h/d 
      (thermoneutral, TN) or 34 degrees C for 8 h/d (heat stress, HS) for 32 d and fed on one 
      of three diets supplemented with 0, 400 or 800 microg of CrHis per kg of diet. Each 
      group consisted of 10 cages, each containing three quail. Data (performance 
      variables and hepatic NF-kappaB and IkappaBalpha) were analysed using 2-way ANOVA. 3. Heat 
      stress caused reductions in cumulative feed intake (FI) by 5.7%, weight gain (WG) 
      by 13.0%, final body weight (FBW) by 10.3%, carcase weight by 12.6% and carcase 
      efficiency by 2.3% and an increase in feed conversion ratio (FCR, feed consumed, 
      g:weight gained, g) by 8.4%. As supplemental CrHis level increased up to 
      800 microg/kg, there were linear increases in cumulative FI (from 602 to 609 g), WG 
      (from 134 to 138 g), FBW (from 167 to 171 g), cold carcase weight (from 110 to 
      114 g) and cold carcase efficiency (from 65.5 to 66.4%) and a decrease in FE 
      (from 4.51 to 4.42). The environmental temperature by CrHis level interaction 
      effect on performance parameters was insignificant. Hepatic NF-kappaB p65 
      concentration was higher and hepatic IkappaBalpha concentration was lower in quail 
      exposed to HS than in quail kept at TN temperature. Increasing supplemental CrHis 
      level linearly inhibited hepatic NF-kappaB p65 expression from 134.4 to 105.3% and 
      linearly enhanced hepatic IkappaBalpha expression from 73.4 to 99.6%. The decrease in 
      hepatic NF-kappaB expression and the increase in hepatic IkappaB expression were more 
      notable in the TN environment than in the HS environment. 4. In conclusion, heat 
      stress depressed performance variables and augmented lipid peroxidation and 
      supplemental CrHis alleviated oxidative stress through modulating expressions of 
      stress-related hepatic nuclear transcription factors (NF-kappaB and IkappaBalpha).
FAU - Orhan, C
AU  - Orhan C
AD  - Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, 
      23119 Elazig, Turkey.
FAU - Akdemir, F
AU  - Akdemir F
FAU - Sahin, N
AU  - Sahin N
FAU - Tuzcu, M
AU  - Tuzcu M
FAU - Komorowski, J R
AU  - Komorowski JR
FAU - Hayirli, A
AU  - Hayirli A
FAU - Sahin, K
AU  - Sahin K
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Br Poult Sci
JT  - British poultry science
JID - 15740290R
RN  - 0 (I-kappa B Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Organometallic Compounds)
RN  - 139874-52-5 (NF-KappaB Inhibitor alpha)
RN  - 1BY3EP7D99 (chromium histidinate)
RN  - 4QD397987E (Histidine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - B-Lymphocytes/metabolism
MH  - Coturnix/genetics/growth & development/*physiology
MH  - Dietary Supplements/*analysis
MH  - Dose-Response Relationship, Drug
MH  - Electrophoresis, Polyacrylamide Gel/veterinary
MH  - Gene Expression Regulation/drug effects
MH  - Heat-Shock Response/*drug effects
MH  - Histidine/administration & dosage/*analogs & derivatives
MH  - Hot Temperature/adverse effects
MH  - I-kappa B Proteins/genetics/metabolism
MH  - Lipid Peroxidation/*drug effects
MH  - Liver/metabolism
MH  - NF-KappaB Inhibitor alpha
MH  - NF-kappa B/genetics/metabolism
MH  - Organometallic Compounds/*administration & dosage
MH  - Oxidative Stress/*drug effects
MH  - Weight Gain/drug effects
EDAT- 2013/02/13 06:00
MHDA- 2013/07/26 06:00
CRDT- 2013/02/13 06:00
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
AID - 10.1080/00071668.2012.747084 [doi]
PST - ppublish
SO  - Br Poult Sci. 2012;53(6):828-35. doi: 10.1080/00071668.2012.747084.