PMID- 23398510
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 81
IP  - 3
DP  - 2013 Mar
TI  - Association of KIR genes and HLA-C alleles with HPV-related uterine cervical 
      disease in Korean women.
PG  - 164-70
LID - 10.1111/tan.12068 [doi]
AB  - This study investigated whether killer-cell immunoglobulin-like receptor (KIR) 
      genes and human leukocyte antigen (HLA)-C alleles, receptors and ligands of 
      natural killer cells are associated with the development of human papillomavirus 
      (HPV)-related cervical disease in Korean women. Blood samples from 132 women with 
      HPV-related cervical disease and 159 women without HPV infection were collected 
      for genotyping of KIR genes and HLA-C alleles. Although no relationship was found 
      between KIR genes and HPV-related cervical disease, a significant relationship 
      was found between HLA-C alleles as ligands of KIR and HPV-related cervical 
      disease. Women with HPV-related cervical disease were found to be significantly 
      more likely to carry HLA-C*0303, particularly those with HPV 16 or 18 infection, 
      and less likely to carry HLA-C*01 compared to women without HPV infection. 
      HLA-C*0303 was found to confer susceptibility to HPV-related cervical disease, 
      whereas HLA-C*01 was found to confer a protective effect against HPV-related 
      cervical disease.
CI  - (c) 2013 John Wiley & Sons A/S.
FAU - Song, M J
AU  - Song MJ
AD  - Department of Obstetrics and Gynecology, College of Medicine, The Catholic 
      University of Korea, Seocho-gu, Seoul, South Korea.
FAU - Lee, C W
AU  - Lee CW
FAU - Kim, J H
AU  - Kim JH
FAU - Lee, S J
AU  - Lee SJ
FAU - Kim, C J
AU  - Kim CJ
FAU - Hur, S Y
AU  - Hur SY
FAU - Park, T C
AU  - Park TC
FAU - Kim, T G
AU  - Kim TG
FAU - Park, J S
AU  - Park JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-C Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Asian People/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-C Antigens/*genetics/immunology
MH  - Humans
MH  - Middle Aged
MH  - Papillomavirus Infections/*genetics/immunology
MH  - Receptors, KIR/*genetics
MH  - Republic of Korea
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/*genetics/immunology/virology
MH  - Young Adult
EDAT- 2013/02/13 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/02/13 06:00
PHST- 2011/10/04 00:00 [received]
PHST- 2013/01/04 00:00 [revised]
PHST- 2013/01/13 00:00 [accepted]
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - 10.1111/tan.12068 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Mar;81(3):164-70. doi: 10.1111/tan.12068.