PMID- 23398855
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 13
IP  - 4
DP  - 2013 Apr
TI  - No impact of KIR-ligand mismatch on allograft outcome in HLA-compatible kidney 
      transplantation.
PG  - 1063-1068
LID - 10.1111/ajt.12134 [doi]
AB  - Natural killer (NK) cell function can be modulated by the killer cell 
      immunoglobulin-like receptors (KIR) which interact with human leukocyte antigen 
      (HLA) class I molecules on target cells. KIR-ligand mismatching has recently been 
      shown by van Bergen et al. (American Journal of Transplantation 2011; 11(9): 
      1959-1964) to be a significant risk factor for long-term graft loss in HLA-A, -B 
      and -DR compatible kidney transplants. To verify this potentially important 
      finding, we performed genotyping of 608 deceased-donor kidney graft recipients 
      and their HLA-A, -B and -DR compatible donors for KIR and HLA, using samples and 
      clinical data provided by the Collaborative Transplant Study. Graft survival of 
      KIR-ligand-matched and -mismatched transplants was compared. We found no impact 
      of KIR-ligand mismatching on 10-year graft survival in HLA-A, -B, -DR compatible 
      kidney transplants. Further analysis did not reveal a significant effect of 
      recipient activating/inhibitory KIR or KIR genotypes on graft survival. Our data 
      do not support the concept that KIR-HLA matching might serve as a tool to improve 
      long-term renal allograft survival.
CI  - (c) Copyright 2013 The American Society of Transplantation and the American Society 
      of Transplant Surgeons.
FAU - Tran, T H
AU  - Tran TH
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Unterrainer, C
AU  - Unterrainer C
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Fiedler, G
AU  - Fiedler G
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Dohler, B
AU  - Dohler B
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Scherer, S
AU  - Scherer S
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Ruhenstroth, A
AU  - Ruhenstroth A
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Adamek, M
AU  - Adamek M
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Middleton, D
AU  - Middleton D
AD  - Transplant Immunology, Royal Liverpool University Hospital, Liverpool, UK.
FAU - Opelz, G
AU  - Opelz G
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20130207
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - Graft Survival
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/*methods
MH  - Ligands
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Receptors, KIR/*metabolism
MH  - Renal Insufficiency/*immunology/surgery
MH  - Risk Factors
MH  - Time Factors
MH  - Young Adult
EDAT- 2013/02/13 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/13 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/11/15 00:00 [revised]
PHST- 2012/12/04 00:00 [accepted]
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1600-6135(22)25912-7 [pii]
AID - 10.1111/ajt.12134 [doi]
PST - ppublish
SO  - Am J Transplant. 2013 Apr;13(4):1063-1068. doi: 10.1111/ajt.12134. Epub 2013 Feb 
      7.