PMID- 23401677
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130213
LR  - 20211021
IS  - 1687-6121 (Print)
IS  - 1687-630X (Electronic)
IS  - 1687-6121 (Linking)
VI  - 2013
DP  - 2013
TI  - Extraesophageal Reflux: What Is the Best Parameter for pH-Monitoring Data 
      Analysis from the Perspective of Patient Response to Proton Pump Inhibitors?
PG  - 736486
LID - 10.1155/2013/736486 [doi]
LID - 736486
AB  - Objectives. To analyze the pH-monitoring records of patients with suspected 
      extraesophageal reflux (EER) using three different parameters (number of refluxes 
      (NOR), acid exposure time (AET), and reflux area index (RAI)), with a view to 
      determining which type of analysis is best at selecting the patients who will 
      respond to a proton pump inhibitor (PPI). Methods. Demographic data were obtained 
      and the level of the complaint was assessed using the Visual Analogue Scale. A 
      dual probe pH-monitoring study was conducted. NOR greater than six, AET more than 
      0.1%, and RAI higher than 6.3 mpH were taken to be the thresholds for EER. 
      Subsequently the response to a 12-week PPI trial was analyzed. Results. A total 
      of 81 patients were analyzed. The percentages of patients with substantial EER 
      based on NOR, AET, and RAI were 36%, 28% and 26%, respectively. Statistically 
      significant, often positive PPI trials were confirmed in the group identified as 
      having substantial EER using all three types of analysis. When using AET and RAI, 
      the significance was more pronounced (P = 0.012 and P = 0.013, resp.) in 
      comparison with NOR (P = 0.033). Conclusions. Patients with EER diagnosed using 
      AET or RAI will respond to PPI significantly often.
FAU - Zelenik, Karol
AU  - Zelenik K
AD  - Department of Otolaryngology, University Hospital Ostrava, 17 Listopadu 1790, 708 
      52 Ostrava, Czech Republic ; Faculty of Medicine, University of Ostrava, 
      Syllabova 19, 703 00 Ostrava, Czech Republic.
FAU - Matousek, Petr
AU  - Matousek P
FAU - Tedla, Miroslav
AU  - Tedla M
FAU - Syrovatka, Jakub
AU  - Syrovatka J
FAU - Kominek, Pavel
AU  - Kominek P
LA  - eng
PT  - Journal Article
DEP - 20130117
PL  - Egypt
TA  - Gastroenterol Res Pract
JT  - Gastroenterology research and practice
JID - 101475557
PMC - PMC3562676
EDAT- 2013/02/13 06:00
MHDA- 2013/02/13 06:01
PMCR- 2013/01/17
CRDT- 2013/02/13 06:00
PHST- 2012/11/18 00:00 [received]
PHST- 2012/12/15 00:00 [revised]
PHST- 2012/12/19 00:00 [accepted]
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/02/13 06:01 [medline]
PHST- 2013/01/17 00:00 [pmc-release]
AID - 10.1155/2013/736486 [doi]
PST - ppublish
SO  - Gastroenterol Res Pract. 2013;2013:736486. doi: 10.1155/2013/736486. Epub 2013 
      Jan 17.