PMID- 23401802
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20220316
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2013
DP  - 2013
TI  - Treadmill exercise induces hippocampal astroglial alterations in rats.
PG  - 709732
LID - 10.1155/2013/709732 [doi]
LID - 709732
AB  - Physical exercise effects on brain health and cognitive performance have been 
      described. Synaptic remodeling in hippocampus induced by physical exercise has 
      been described in animal models, but the underlying mechanisms remain poorly 
      understood. Changes in astrocytes, the glial cells involved in synaptic 
      remodeling, need more characterization. We investigated the effect of moderate 
      treadmill exercise (20 min/day) for 4 weeks on some parameters of astrocytic 
      activity in rat hippocampal slices, namely, glial fibrillary acidic protein 
      (GFAP), glutamate uptake and glutamine synthetase (GS) activities, glutathione 
      content, and S100B protein content and secretion, as well as brain-derived 
      neurotrophic factor (BDNF) levels and glucose uptake activity in this tissue. 
      Results show that moderate treadmill exercise was able to induce a decrease in 
      GFAP content (evaluated by ELISA and immunohistochemistry) and an increase in GS 
      activity. These changes could be mediated by corticosterone, whose levels were 
      elevated in serum. BDNF, another putative mediator, was not altered in 
      hippocampal tissue. Moreover, treadmill exercise caused a decrease in NO content. 
      Our data indicate specific changes in astrocyte markers induced by physical 
      exercise, the importance of studying astrocytes for understanding brain 
      plasticity, as well as reinforce the relevance of physical exercise as a 
      neuroprotective strategy.
FAU - Bernardi, Caren
AU  - Bernardi C
AD  - Programa de Pos-Graduacao em Neurociencias, Instituto de Ciencias Basicas da 
      Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
FAU - Tramontina, Ana Carolina
AU  - Tramontina AC
FAU - Nardin, Patricia
AU  - Nardin P
FAU - Biasibetti, Regina
AU  - Biasibetti R
FAU - Costa, Ana Paula
AU  - Costa AP
FAU - Vizueti, Adriana Fernanda
AU  - Vizueti AF
FAU - Batassini, Cristiane
AU  - Batassini C
FAU - Tortorelli, Lucas Silva
AU  - Tortorelli LS
FAU - Wartchow, Krista Mineia
AU  - Wartchow KM
FAU - Dutra, Marcio Ferreira
AU  - Dutra MF
FAU - Bobermin, Larissa
AU  - Bobermin L
FAU - Sesterheim, Patricia
AU  - Sesterheim P
FAU - Quincozes-Santos, Andre
AU  - Quincozes-Santos A
FAU - de Souza, Jaqueline
AU  - de Souza J
FAU - Goncalves, Carlos Alberto
AU  - Goncalves CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130117
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Astrocytes/*physiology
MH  - Corticosterone/blood
MH  - Exercise Test/*methods
MH  - Hippocampus/*cytology/*physiology
MH  - Male
MH  - Physical Conditioning, Animal/*methods
MH  - Rats
MH  - Rats, Wistar
PMC - PMC3562665
EDAT- 2013/02/13 06:00
MHDA- 2013/10/30 06:00
PMCR- 2013/01/17
CRDT- 2013/02/13 06:00
PHST- 2012/09/03 00:00 [received]
PHST- 2012/11/23 00:00 [revised]
PHST- 2012/12/03 00:00 [accepted]
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
PHST- 2013/01/17 00:00 [pmc-release]
AID - 10.1155/2013/709732 [doi]
PST - ppublish
SO  - Neural Plast. 2013;2013:709732. doi: 10.1155/2013/709732. Epub 2013 Jan 17.