PMID- 23401810
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130213
LR  - 20211021
IS  - 2090-6544 (Print)
IS  - 2090-6552 (Electronic)
IS  - 2090-6552 (Linking)
VI  - 2013
DP  - 2013
TI  - Detection of t(14;16)(q32;q22) and Monosomy 13 by FISH Analysis in a Patient with 
      Multiple Myeloma Associated with Sjogren's Syndrome: The First Case Report from 
      India.
PG  - 279801
LID - 10.1155/2013/279801 [doi]
LID - 279801
AB  - Sjogren's syndrome (SS) is a chronic slowly progressive autoimmune disorder 
      characterized by symptoms of oral and ocular dryness, exocrine dysfunction, and 
      lymphocytic infiltration of exocrine glands. Multiple myeloma (MM) is a 
      bone-marrow-based malignant neoplasm of plasma cells associated with serum/urine 
      monoclonal paraproteins and lytic skeletal lesions. There have been very few 
      reported cases of MM, who had SS as the first presentation. We report a case of a 
      woman diagnosed with Sjogren's syndrome, who was later suspected to have multiple 
      myeloma on serum protein electrophoresis. Fluorescence in situ hybridization 
      (FISH) was carried out to check for deletions of loci 13q14.3, ATM, p53, and IGH 
      (14q32) rearrangements on a bone marrow aspirate. Monosomy 13 was observed in 49% 
      of cells, and a rearrangement at the IGH locus was seen in 42% of cells. To 
      determine the partner chromosome associated with the IGH rearrangement, further 
      FISH tests were set up for t(4;14)(p16;q32) followed by t(14;16)(q32;q22) on 
      fresh slides. The test was negative for t(4;14) but positive for t(14;16) in 27% 
      of cells. This confirmed the diagnosis of MM. We report the first case from 
      India, having an association of Sjogren's syndrome with multiple myeloma, which 
      showed t(14;16) and monosomy 13 by FISH analysis.
FAU - Sanap, Rupesh R
AU  - Sanap RR
AD  - Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research 
      Centre, 15 Dr. G. Deshmukh Marg, Mumbai 400026, India.
FAU - Athalye, Arundhati S
AU  - Athalye AS
FAU - Madon, Prochi F
AU  - Madon PF
FAU - Dhabhar, Boman N
AU  - Dhabhar BN
FAU - Sute, Mahendra B
AU  - Sute MB
FAU - Mahabale, Amit A
AU  - Mahabale AA
FAU - Warang, Dhanashree J
AU  - Warang DJ
FAU - Parikh, Firuza R
AU  - Parikh FR
LA  - eng
PT  - Journal Article
DEP - 20130116
PL  - United States
TA  - Case Rep Genet
JT  - Case reports in genetics
JID - 101583302
PMC - PMC3562653
EDAT- 2013/02/13 06:00
MHDA- 2013/02/13 06:01
PMCR- 2013/01/16
CRDT- 2013/02/13 06:00
PHST- 2012/11/30 00:00 [received]
PHST- 2012/12/23 00:00 [accepted]
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/02/13 06:01 [medline]
PHST- 2013/01/16 00:00 [pmc-release]
AID - 10.1155/2013/279801 [doi]
PST - ppublish
SO  - Case Rep Genet. 2013;2013:279801. doi: 10.1155/2013/279801. Epub 2013 Jan 16.