PMID- 2340204
OWN - NLM
STAT- MEDLINE
DCOM- 19900626
LR  - 20041117
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 6
IP  - 4
DP  - 1990 Apr
TI  - Production of tumor necrosis factor-alpha and interleukin-1 by alveolar 
      macrophages from HIV-1-infected persons.
PG  - 431-41
AB  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) are potent 
      immunomodulatory cytokines which are produced principally by cells of the 
      macrophage-monocyte lineage. We conducted an investigation to assess the 
      secretion of these cytokines by bronchoalveolar macrophages from patients with 
      progressive stages of human immunodeficiency virus (HIV-1) infection. The mean 
      level of TNF-alpha produced by macrophages from 9 patients with AIDS was 
      significantly reduced compared with the responses of macrophages from 6 healthy 
      HIV-1-seronegative persons, 6 patients with either asymptomatic HIV-1 infection 
      or persistent generalized lymphadenopathy, and 6 patients with AIDS-related 
      complex (ARC). The four study groups did not differ in their mean IL-1 beta 
      responses. However, within the HIV-1-infected patient population, macrophages 
      from 4 patients, 3 of whom had AIDS and 1 with ARC, failed to secrete detectable 
      levels of IL-1 beta. All 4 patients were also nonresponsive in assays for 
      TNF-alpha. These data establish that advanced HIV-1 infection may result in a 
      pronounced dysfunction in the cytokine responses of alveolar macrophages.
FAU - Cox, R A
AU  - Cox RA
AD  - Department of Research Immunology, San Antonio State Chest Hospital, TX 78223.
FAU - Anders, G T
AU  - Anders GT
FAU - Cappelli, P J
AU  - Cappelli PJ
FAU - Johnson, J E
AU  - Johnson JE
FAU - Blanton, H M
AU  - Blanton HM
FAU - Seaworth, B J
AU  - Seaworth BJ
FAU - Treasure, R L
AU  - Treasure RL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (Interleukin-1)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*immunology
MH  - Adult
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - *HIV-1
MH  - Humans
MH  - Interleukin-1/*biosynthesis
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophages/*metabolism
MH  - Pulmonary Alveoli/metabolism
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
EDAT- 1990/04/01 00:00
MHDA- 1990/04/01 00:01
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 1990/04/01 00:01 [medline]
PHST- 1990/04/01 00:00 [entrez]
AID - 10.1089/aid.1990.6.431 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 1990 Apr;6(4):431-41. doi: 10.1089/aid.1990.6.431.