PMID- 23402493
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130222
LR  - 20211021
IS  - 1550-2783 (Print)
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 10
IP  - 1
DP  - 2013 Feb 12
TI  - Co-ingestion of carbohydrate and whey protein isolates enhance PGC-1alpha mRNA 
      expression: a randomised, single blind, cross over study.
PG  - 8
LID - 10.1186/1550-2783-10-8 [doi]
AB  - BACKGROUND: Whey protein isolates (WPI) supplementation is known to improve 
      resistance training adaptations. However, limited information is available on the 
      effects of WPI plus carbohydrate (CHO) supplementation on endurance training 
      adaptations. METHOD: Six endurance trained male cyclists and triathletes (age 
      29 +/- 4 years, weight 74 +/- 2 kg, VO2 max 63 +/- 3 ml oxygen. kg-1. Min-1, height 
      183 +/- 5 cm; mean +/- SEM) were randomly assigned to one of two dietary 
      interventions in a single blind cross over design; CHO or CHO + WPI. Each dietary 
      intervention was followed for 16 days which included the last 2 days having 
      increased CHO content, representing a CHO loading phase. The dietary 
      interventions were iso-caloric and carbohydrate content matched. On completion of 
      the dietary intervention, participants performed an exercise bout, consisting of 
      cycling for 60 min at 70% VO2 max, followed by time trial to exhaustion at 90% 
      VO2 max and recovered in the laboratory for 6 hours. Blood samples and muscle 
      biopsies were taken at various time points at rest and through the exercise trial 
      and recovery. RESULTS: Compared to CHO, CHO + WPI increased plasma insulin during 
      recovery at 180 mins (P < 0.05) and peroxisome proliferator-activated receptor 
      gamma coactivator-1 alpha (PGC-1alpha) mRNA expression at the end of 6 hours of 
      recovery (P < 0.05). Muscle glycogen did not differ between the two trials. 
      CONCLUSION: This study showed co-ingestion of CHO + WPI may have beneficial 
      effects on recovery and adaptations to endurance exercise via, increased insulin 
      response and up regulation of PGC-1alpha mRNA expression.
FAU - Hill, Karen M
AU  - Hill KM
AD  - Biomedical and Lifestyle Diseases Unit, College of Health and Biomedicine, 
      Victoria University, PO Box 14428, Melbourne, VIC 8001, Australia. 
      andrew.mcainch@vu.edu.au.
FAU - Stathis, Christos G
AU  - Stathis CG
FAU - Grinfeld, Esther
AU  - Grinfeld E
FAU - Hayes, Alan
AU  - Hayes A
FAU - McAinch, Andrew J
AU  - McAinch AJ
LA  - eng
PT  - Journal Article
DEP - 20130212
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
PMC - PMC3577454
EDAT- 2013/02/14 06:00
MHDA- 2013/02/14 06:01
PMCR- 2013/02/12
CRDT- 2013/02/14 06:00
PHST- 2012/09/13 00:00 [received]
PHST- 2013/02/07 00:00 [accepted]
PHST- 2013/02/14 06:00 [entrez]
PHST- 2013/02/14 06:00 [pubmed]
PHST- 2013/02/14 06:01 [medline]
PHST- 2013/02/12 00:00 [pmc-release]
AID - 1550-2783-10-8 [pii]
AID - 10.1186/1550-2783-10-8 [doi]
PST - epublish
SO  - J Int Soc Sports Nutr. 2013 Feb 12;10(1):8. doi: 10.1186/1550-2783-10-8.