PMID- 23402850
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20130415
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Stress effects on BDNF expression: effects of age, sex, and form of stress.
PG  - 149-56
LID - S0306-4522(13)00121-8 [pii]
LID - 10.1016/j.neuroscience.2013.01.074 [doi]
AB  - Stress has long been associated with the development of neuropsychiatric and 
      neurological disorders. The effects of stress vary depending upon the age during 
      which the stress is incurred, the duration and severity of the stressor, and can 
      further be influenced by levels of circulating gonadal hormones. To date, the 
      majority of research investigating the link between stress and pathology 
      development has focused on stress hormone secretion, receptor activity, and their 
      impact on neuronal development and functioning in developing and adult male and 
      female rodents. In recent years, work has begun to focus on additional 
      neuromodulatory systems that may be significantly impacted by stress that may 
      explain changes in developmental and sex-based susceptibility to stress. New 
      research targets include molecules that play a role in neuronal development and 
      plasticity. Specifically, stress-induced alterations in growth factors such as 
      neurotrophins, in particular brain-derived neurotrophic factor (BDNF), have been 
      identified as a strong candidate modulating stress-associated pathology. 
      Furthermore, changing expression of BDNF and its receptors over development and 
      in response to circulating gonadal hormones extend the attractiveness of this 
      candidate signaling pathway for understanding differences in susceptibility to 
      stress. This review focuses on what is known with regard to the effects of stress 
      on neurotrophin expression in rodents, and the varied effects of stress on BDNF 
      levels as a function of developmental status and sex.
CI  - Copyright (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Bath, K G
AU  - Bath KG
AD  - Department of Neuroscience, Brown University, Box GL-N, 185 Meeting Street, 
      Providence, RI 02912, USA. Kevin_Bath@Brown.edu
FAU - Schilit, A
AU  - Schilit A
FAU - Lee, F S
AU  - Lee FS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130210
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Male
MH  - Sex Characteristics
MH  - Stress, Physiological/*physiology
EDAT- 2013/02/14 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/02/14 06:00
PHST- 2012/10/08 00:00 [received]
PHST- 2012/11/17 00:00 [revised]
PHST- 2013/01/31 00:00 [accepted]
PHST- 2013/02/14 06:00 [entrez]
PHST- 2013/02/14 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0306-4522(13)00121-8 [pii]
AID - 10.1016/j.neuroscience.2013.01.074 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:149-56. doi: 10.1016/j.neuroscience.2013.01.074. 
      Epub 2013 Feb 10.