PMID- 23403101 OWN - NLM STAT- MEDLINE DCOM- 20130711 LR - 20130318 IS - 1872-7972 (Electronic) IS - 0304-3940 (Linking) VI - 538 DP - 2013 Mar 22 TI - Treadmill exercise and wheel exercise enhance expressions of neutrophic factors in the hippocampus of lipopolysaccharide-injected rats. PG - 54-9 LID - S0304-3940(13)00081-5 [pii] LID - 10.1016/j.neulet.2013.01.039 [doi] AB - Brain inflammation plays a pivotal role in the pathogenesis of chronic neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. We investigated the effects of treadmill exercise and wheel exercise on spatial learning ability in relation with long-term potentiation (LTP) using lipopolysaccharide-induced brain inflammation in the rats. Brain inflammation was induced by an injection of LPS into the cerebral ventricle. We found that brain inflammation impaired spatial learning ability and suppressed the induction of LTP in the hippocampus, as well as weakening expressions of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (Trk-B) with the phosphorylated cyclic AMP response element binding protein (p-CREB). Both treadmill exercise and wheel exercise significantly improved spatial learning ability deteriorated by brain inflammation. These effects can be ascribed to the long-lasting effect of exercise on LTP through enhancement of the expressions regarding BDNF, TrkB, and p-CREB. Treadmill exercise and wheel exercise exerted similar effects on these factors. We infer that exercise may alleviate brain inflammation-induced learning impairment. CI - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved. FAU - Kim, Sung-Eun AU - Kim SE AD - Department of Physiology, College of Medicine, Kyung Hee University, Dongdaemoon-gu, Seoul 130-701, Republic of Korea. FAU - Ko, Il-Gyu AU - Ko IG FAU - Shin, Mal-Soon AU - Shin MS FAU - Kim, Chang-Ju AU - Kim CJ FAU - Jin, Byung-Kwan AU - Jin BK FAU - Hong, Hoon-Pyo AU - Hong HP FAU - Jee, Yong-Seok AU - Jee YS LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130208 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cyclic AMP Response Element-Binding Protein) RN - 0 (Lipopolysaccharides) RN - 0 (Nerve Growth Factors) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/metabolism MH - Cyclic AMP Response Element-Binding Protein/metabolism MH - Hippocampus/drug effects/*metabolism MH - Inflammation/metabolism MH - Injections, Intraventricular MH - *Learning MH - Lipopolysaccharides/*pharmacology MH - Long-Term Potentiation MH - Male MH - Maze Learning MH - Mossy Fibers, Hippocampal/physiology MH - Nerve Growth Factors/*metabolism MH - Phosphorylation MH - *Physical Conditioning, Animal MH - Rats MH - Rats, Sprague-Dawley MH - Receptor, trkB/metabolism EDAT- 2013/02/14 06:00 MHDA- 2013/07/13 06:00 CRDT- 2013/02/14 06:00 PHST- 2012/10/19 00:00 [received] PHST- 2012/12/23 00:00 [revised] PHST- 2013/01/19 00:00 [accepted] PHST- 2013/02/14 06:00 [entrez] PHST- 2013/02/14 06:00 [pubmed] PHST- 2013/07/13 06:00 [medline] AID - S0304-3940(13)00081-5 [pii] AID - 10.1016/j.neulet.2013.01.039 [doi] PST - ppublish SO - Neurosci Lett. 2013 Mar 22;538:54-9. doi: 10.1016/j.neulet.2013.01.039. Epub 2013 Feb 8.