PMID- 23403376
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20211021
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 33
IP  - 5
DP  - 2013 May
TI  - An MRI-histological study of white matter in stroke-free SHRSP.
PG  - 760-3
LID - 10.1038/jcbfm.2013.14 [doi]
AB  - Hypertension is associated with cerebral small vessel disease (SVD) and with 
      diffuse white matter hyperintensities (WMH) on T2-weighted magnetic resonance 
      imaging (MRI). We tested whether stroke-prone spontaneously hypertensive rats 
      (SHRSP), a model of chronic hypertension, exhibit WMH. Male SHRSP (age 10 months) 
      without stroke symptoms were compared with age-matched male WKY rats. 
      Stroke-prone spontaneously hypertensive rats exhibited no WMH on MRI scans (T2, 
      T2*, diffusion tensor imaging) and no neuropathological lesions. While 
      leptomeningeal arteries exhibited fibrohyaline wall thickening, with decreased 
      smooth muscle actin relative to WKY, deep penetrating arterioles within the 
      caudate nuclei had no vasculopathy. We conclude that WMH are not an obligate 
      feature of stroke-free SHRSP aged up to 10 months.
FAU - Brittain, John F
AU  - Brittain JF
AD  - Stroke and Dementia Research Centre, St Georges University of London, London, UK.
FAU - McCabe, Christopher
AU  - McCabe C
FAU - Khatun, Halima
AU  - Khatun H
FAU - Kaushal, Nitika
AU  - Kaushal N
FAU - Bridges, Leslie R
AU  - Bridges LR
FAU - Holmes, William M
AU  - Holmes WM
FAU - Barrick, Thomas R
AU  - Barrick TR
FAU - Graham, Delyth
AU  - Graham D
FAU - Dominiczak, Anna F
AU  - Dominiczak AF
FAU - Mhairi Macrae, I
AU  - Mhairi Macrae I
FAU - Hainsworth, Atticus H
AU  - Hainsworth AH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130213
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Myelin Basic Protein)
SB  - IM
MH  - Animals
MH  - Brain/blood supply/*pathology
MH  - Cerebral Arteries/pathology
MH  - Hypertension/*complications
MH  - Leukoencephalopathies/complications/*pathology
MH  - Male
MH  - Myelin Basic Protein/analysis
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Stroke/*complications
PMC - PMC3652693
EDAT- 2013/02/14 06:00
MHDA- 2013/07/03 06:00
PMCR- 2014/05/01
CRDT- 2013/02/14 06:00
PHST- 2013/02/14 06:00 [entrez]
PHST- 2013/02/14 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - jcbfm201314 [pii]
AID - 10.1038/jcbfm.2013.14 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2013 May;33(5):760-3. doi: 10.1038/jcbfm.2013.14. Epub 
      2013 Feb 13.