PMID- 23403742
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20230211
IS  - 1752-2978 (Electronic)
IS  - 1752-296X (Linking)
VI  - 20
IP  - 2
DP  - 2013 Apr
TI  - Metabolic surgery for type 2 diabetes: efficacy and risks.
PG  - 98-105
LID - 10.1097/MED.0b013e32835edbb0 [doi]
AB  - PURPOSE OF REVIEW: Bariatric surgery has emerged as a highly effective treatment 
      for obesity and is increasingly recognized to have benefits for glycemic 
      management in patients with pre-existing type 2 diabetes mellitus (T2DM), and for 
      diabetes prevention. This article will review the efficacy and mechanisms of 
      metabolic surgery for the treatment of T2DM. RECENT FINDINGS: Recent small 
      randomized studies with 1-2 years of follow-up begin to provide level 1 data of 
      the effects of surgical procedures compared to medical management on glycemic 
      control. Physiology studies using sophisticated metabolic techniques to evaluate 
      insulin secretion, action, and entero-endocrine changes in patients 
      preoperatively and postoperatively have shed light on the mechanisms that lead to 
      changes in glycemia observed after bariatric surgery. SUMMARY: Understanding the 
      efficacy and physiologic effects of bariatric surgery on metabolism will help 
      guide patient management in the context of a growing epidemic of obesity and 
      T2DM, and may also ultimately enable us to develop less invasive but equally 
      effective therapeutic strategies for weight loss and metabolic control.
FAU - Halperin, Florencia
AU  - Halperin F
AD  - Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
FAU - Goldfine, Allison B
AU  - Goldfine AB
LA  - eng
GR  - 1R56DK095451-01/DK/NIDDK NIH HHS/United States
GR  - 5RC1DK086918-02/DK/NIDDK NIH HHS/United States
GR  - UL1 RR 025758/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Curr Opin Endocrinol Diabetes Obes
JT  - Current opinion in endocrinology, diabetes, and obesity
JID - 101308636
RN  - 0 (Blood Glucose)
SB  - IM
MH  - *Bariatric Surgery/adverse effects/methods
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/blood/complications/*surgery
MH  - Follow-Up Studies
MH  - Hyperinsulinism/blood/*etiology
MH  - Hypoglycemia/blood/*etiology
MH  - Intestinal Absorption
MH  - Obesity, Morbid/blood/complications/*surgery
MH  - Outcome Assessment, Health Care
MH  - Patient Selection
MH  - Postoperative Complications/blood/physiopathology
MH  - Pulmonary Embolism/blood/*etiology
MH  - Randomized Controlled Trials as Topic
MH  - Remission Induction
MH  - Sepsis/blood/*etiology
MH  - Treatment Outcome
MH  - Weight Loss
EDAT- 2013/02/14 06:00
MHDA- 2013/09/27 06:00
CRDT- 2013/02/14 06:00
PHST- 2013/02/14 06:00 [entrez]
PHST- 2013/02/14 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
AID - 10.1097/MED.0b013e32835edbb0 [doi]
PST - ppublish
SO  - Curr Opin Endocrinol Diabetes Obes. 2013 Apr;20(2):98-105. doi: 
      10.1097/MED.0b013e32835edbb0.