PMID- 23404106
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20230614
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 140
IP  - 5
DP  - 2013 Mar
TI  - The transcriptional co-factor RIP140 regulates mammary gland development by 
      promoting the generation of key mitogenic signals.
PG  - 1079-89
LID - 10.1242/dev.085720 [doi]
AB  - Nuclear receptor interacting protein (Nrip1), also known as RIP140, is a 
      co-regulator for nuclear receptors that plays an essential role in ovulation by 
      regulating the expression of the epidermal growth factor-like family of growth 
      factors. Although several studies indicate a role for RIP140 in breast cancer, 
      its role in the development of the mammary gland is unclear. By using RIP140-null 
      and RIP140 transgenic mice, we demonstrate that RIP140 is an essential factor for 
      normal mammary gland development and that it functions by mediating oestrogen 
      signalling. RIP140-null mice exhibit minimal ductal elongation with no 
      side-branching, whereas RIP140-overexpressing mice show increased cell 
      proliferation and ductal branching with age. Tissue recombination experiments 
      demonstrate that RIP140 expression is required in both the mammary epithelial and 
      stromal compartments for ductal elongation during puberty and that loss of RIP140 
      leads to a catastrophic loss of the mammary epithelium, whereas RIP140 
      overexpression augments the mammary basal cell population and shifts the 
      progenitor/differentiated cell balance within the luminal cell compartment 
      towards the progenitors. For the first time, we present a genome-wide global view 
      of oestrogen receptor-alpha (ERalpha) binding events in the developing mammary gland, 
      which unravels 881 ERalpha binding sites. Unbiased evaluation of several ERalpha binding 
      sites for RIP140 co-occupancy reveals selectivity and demonstrates that RIP140 
      acts as a co-regulator with ERalpha to regulate directly the expression of 
      amphiregulin (Areg), the progesterone receptor (Pgr) and signal transducer and 
      activator of transcription 5a (Stat5a), factors that influence key mitogenic 
      pathways that regulate normal mammary gland development.
FAU - Nautiyal, Jaya
AU  - Nautiyal J
AD  - Institute of Reproductive and Developmental Biology, Faculty of Medicine, 
      Imperial College London, Du Cane Road, London W12 0NN, UK.
FAU - Steel, Jennifer H
AU  - Steel JH
FAU - Mane, Meritxell Rosell
AU  - Mane MR
FAU - Oduwole, Olayiwola
AU  - Oduwole O
FAU - Poliandri, Ariel
AU  - Poliandri A
FAU - Alexi, Xanthippi
AU  - Alexi X
FAU - Wood, Nicholas
AU  - Wood N
FAU - Poutanen, Matti
AU  - Poutanen M
FAU - Zwart, Wilbert
AU  - Zwart W
FAU - Stingl, John
AU  - Stingl J
FAU - Parker, Malcolm G
AU  - Parker MG
LA  - eng
GR  - 079200/Z/06/Z/WT_/Wellcome Trust/United Kingdom
GR  - 079249/WT_/Wellcome Trust/United Kingdom
GR  - BB/C504327/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - 10208/CRUK_/Cancer Research UK/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Growth Substances)
RN  - 0 (Nrip1 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nuclear Receptor Interacting Protein 1)
RN  - 0 (Transcription Factors)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/genetics/metabolism/*physiology
MH  - Animals
MH  - Cells, Cultured
MH  - Estradiol/pharmacology
MH  - Female
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Growth Substances/*genetics/metabolism
MH  - Mammary Glands, Animal/drug effects/*growth & development/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Morphogenesis/drug effects/genetics/physiology
MH  - NIH 3T3 Cells
MH  - Nuclear Proteins/genetics/metabolism/*physiology
MH  - Nuclear Receptor Interacting Protein 1
MH  - Signal Transduction/drug effects/genetics
MH  - Transcription Factors/genetics/metabolism/physiology
PMC - PMC3583043
EDAT- 2013/02/14 06:00
MHDA- 2013/04/17 06:00
PMCR- 2013/03/01
CRDT- 2013/02/14 06:00
PHST- 2013/02/14 06:00 [entrez]
PHST- 2013/02/14 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - 140/5/1079 [pii]
AID - 10.1242/dev.085720 [doi]
PST - ppublish
SO  - Development. 2013 Mar;140(5):1079-89. doi: 10.1242/dev.085720.