PMID- 23404111
OWN - NLM
STAT- MEDLINE
DCOM- 20140725
LR  - 20211203
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 7
IP  - 4
DP  - 2013 Apr
TI  - Hcrcn81 is upregulated by rapamycin treatment in human colorectal adenocarcinoma 
      cells.
PG  - 1257-60
LID - 10.3892/mmr.2013.1317 [doi]
AB  - The aim of the present study was to determine the role of hcrcn81 in the 
      regulation of the mammalian target of rapamycin (mTOR) pathway in human 
      colorectal adenocarcinoma cells. The effect of rapamycin treatment on hcrcn81 
      expression was evaluated by examining the mRNA and protein expression of hcrcn81 
      in rapamycin‑treated human colon carcinoma cell lines, SW480 and LoVo, using 
      real‑time PCR and western blot analysis, respectively. The results demonstrated 
      that mRNA and protein levels of hcrcn81 were elevated following rapamycin 
      treatment in these cell lines, indicating that hcrcn81 expression is upregulated 
      by rapamycin treatment in human colorectal adenocarcinoma cells. Observations of 
      the current study indicate that hcrcn81 may play a role in tumorigenesis by 
      regulating the mTOR signaling pathway.
FAU - Wen, Xiaoxia
AU  - Wen X
AD  - Department of Anatomy, Basic Medical and Forensic Medical Institute, Sichuan 
      University, Chengdu, Sichuan 610041, P.R. China.
FAU - Dong, Lei
AU  - Dong L
FAU - Zhu, Jianjun
AU  - Zhu J
FAU - Chen, Yao
AU  - Chen Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130208
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (HCRCN81 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Adenocarcinoma/*genetics/pathology
MH  - *Carcinogenesis
MH  - Cell Line, Tumor
MH  - Colorectal Neoplasms/*genetics/pathology
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - Neoplasm Proteins/*biosynthesis/genetics
MH  - Signal Transduction/genetics
MH  - Sirolimus/pharmacology
MH  - TOR Serine-Threonine Kinases/genetics
EDAT- 2013/02/14 06:00
MHDA- 2014/07/26 06:00
CRDT- 2013/02/14 06:00
PHST- 2012/10/31 00:00 [received]
PHST- 2013/02/01 00:00 [accepted]
PHST- 2013/02/14 06:00 [entrez]
PHST- 2013/02/14 06:00 [pubmed]
PHST- 2014/07/26 06:00 [medline]
AID - 10.3892/mmr.2013.1317 [doi]
PST - ppublish
SO  - Mol Med Rep. 2013 Apr;7(4):1257-60. doi: 10.3892/mmr.2013.1317. Epub 2013 Feb 8.