PMID- 23406590
OWN - NLM
STAT- MEDLINE
DCOM- 20130807
LR  - 20151119
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - Plasma paraoxonase activity and oxidative stress and their relationship to 
      disease severity in children with allergic rhinitis.
PG  - 13-7
LID - 10.2500/ajra.2013.27.3837 [doi]
AB  - BACKGROUND: Oxidative stress may play a role in the pathophysiology of several 
      diseases including allergic rhinitis (AR). In children with AR an antioxidant 
      enzyme paraoxonase (PON1) has not been previously investigated. The aim of this 
      study was to investigate plasma PON1 activity and plasma total oxidant status 
      (TOS), which are in the form of plasma reactive oxidants, and their association 
      with severity of disease in house-mite-sensitive children with AR. METHODS: This 
      study included 66 children with persistent AR and 40 healthy controls aged 
      between 7 and 12 years old. Plasma PON1, TOS, and total serum immunoglobulin E 
      (IgE) were measured. The nasal symptom scores and body mass index were evaluated 
      at the time of blood collection. RESULTS: Mean serum PON1 levels were 
      significantly lower and, TOS levels were higher in the patient group than in the 
      control group (p </= 0.001 and p </= 0.002, respectively). A significant negative 
      correlation was observed between serum levels of PON1 and nasal symptom scores. 
      However, serum levels of TOS were correlated with nasal symptom scores 
      positively. There were no correlations between levels of total IgE and levels of 
      PON1 and TOS levels. CONCLUSION: Plasma PON1 and TOS levels may serve as 
      predictors of disease severity in children with AR and both of them appear to be 
      attractive candidates for modulating inflammation in AR.
FAU - Ozkaya, Emin
AU  - Ozkaya E
AD  - Division of Pediatric Allergy, Bezmialem Vakif University, Istanbul, Turkey. 
      minozkaya@yahoo.com
FAU - Akduman, Hasan
AU  - Akduman H
FAU - Erenberk, Ufuk
AU  - Erenberk U
FAU - Demir, Aysegul
AU  - Demir A
FAU - Dundaroz, M Rusen
AU  - Dundaroz MR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Biomarkers)
RN  - 0 (Oxidants)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
SB  - IM
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology
MH  - Aryldialkylphosphatase/*blood
MH  - Biomarkers/blood
MH  - Child
MH  - Disease Progression
MH  - Enzyme Activation
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Oxidants/blood
MH  - Oxidative Stress/*immunology
MH  - Prognosis
MH  - Pyroglyphidae/immunology
MH  - Rhinitis, Allergic, Perennial/blood/*diagnosis/immunology
EDAT- 2013/02/15 06:00
MHDA- 2013/08/08 06:00
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2013/08/08 06:00 [medline]
AID - 10.2500/ajra.2013.27.3837 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2013 Jan;27(1):13-7. doi: 10.2500/ajra.2013.27.3837.