PMID- 23406938
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20221207
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 34
IP  - 1
DP  - 2013 Jan-Feb
TI  - Adverse drug effects and angioedema hospitalizations in the United States from 
      2000 to 2009.
PG  - 65-71
LID - 10.2500/aap.2013.34.3618 [doi]
AB  - Since angiotensin-converting enzyme (ACE) inhibitors became common treatments, 
      there have been increasing reports of angioedema (AE). AE hospitalization (AEH) 
      trend data in the new millennium are limited. This study calculates 
      hospitalization rates for AEs and describes clinical characteristics of AEHs in 
      the United States, especially as related to specific adverse drug effects (ADEs). 
      The National Inpatient Samples 2000-2009 were queried for AEHs to calculate 
      hospitalization rates and to examine for associations with specified ADEs, 
      certain comorbidities, and demographic features. AEHs requiring intubation or 
      tracheostomy were also examined for associations. There was a significant 
      increase in the AEH rates (3.4 per 10(5) to 5.4 per 10(5)) over the study period 
      (p < 0.0001) and the hospitalization rates for African Americans (AAs) were 
      consistently higher. Throughout the study the proportions of AEH coding any ADEs, 
      or an ADE due to a cardiovascular (CV) or antihypertensive (aHTN) drug increased 
      over time. By 2009, 61.7% AEHs coded an ADE. Of these, 58.7% were caused by CV or 
      aHTN drugs. In AEHs, having an ADE from a CV or aHTN medication had the strongest 
      adjusted associations with hypertension and renal disease as well as with 
      alcohol-related disorders. In AEHs, intubation/tracheostomy had the strongest ADE 
      associations related to CV or aHTN medication (adjusted odds ratio, 1.4; 95% CI, 
      1.3, 1.6). AEHs continue to increase, but this can only be partially attributed 
      to ACE inhibitor usage. Intubation/tracheostomy appears to be greater in AEHs 
      with ADE due to CV/aHTN drugs. Alcohol-related disorders may have a role in ACE 
      inhibitor-associated AEH.
FAU - Lin, Robert Y
AU  - Lin RY
AD  - Department of Medicine, New York Downtown Hospital, New York, NY 10038, USA. 
      robert.lin@downtownhospital.org
FAU - Levine, Rozalyn J
AU  - Levine RJ
FAU - Lin, Huei
AU  - Lin H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - *Black or African American
MH  - Angioedema/chemically induced/*epidemiology/surgery
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/*adverse effects
MH  - Antihypertensive Agents/administration & dosage/*adverse effects
MH  - Cardiovascular Diseases/complications/*drug therapy
MH  - Female
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Tracheostomy/statistics & numerical data
MH  - United States
EDAT- 2013/02/15 06:00
MHDA- 2013/08/07 06:00
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.2500/aap.2013.34.3618 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2013 Jan-Feb;34(1):65-71. doi: 10.2500/aap.2013.34.3618.