PMID- 23406942
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20161020
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 34
IP  - 1
DP  - 2013 Jan-Feb
TI  - Evolutionary immune response to conserved domains in parasites and aeroallergens.
PG  - 93-102
LID - 10.2500/aap.2013.34.3616 [doi]
AB  - The immune response based on immunoglobulin E (IgE) evolved as a defense against 
      specific parasitic infections. In the absence of active helminthic infections, 
      the immune system has redirected its IgE epitopes toward innocuous environmental 
      antigens. Helminths and aeroallergens have a similar stereotypical IgE response 
      to unique antigens that can not be explained by chance alone. This study was 
      designed to evaluate potential homology between conserved protein domains 
      embedded in parasitic organisms and aeroallergens. Search and retrieval systems 
      for nucleotide and protein sequences (Entrez, BLAST, and National Center for 
      Biotechnology Information) were searched to identify conserved domains between 
      allergens and certain parasites. A total score was developed that correlated 
      positively with homology between compared sequences. Over 2000 domains were 
      examined. We found matches with a high total score (>100) that signified a strong 
      positive correlation between sequences in allergens (n = 30) and parasites (n = 
      13). Multiple shared conserved domains were identified between parasites and 
      allergens. Parasite-allergen combinations with the most significant homology 
      (greatest total score) were Plasmodium falciparum enolase and Hev b9 (total 
      score, 612), Schistosoma mansoni albumin and Fel d 2 (total score, 991), Ascaris 
      lumbricoides tropomyosin and Ani s3 (total score, 531), and Wuchereria bancrofti 
      trypsin and Blo t3 (138). Homologous conserved domains exist in specific 
      parasites and allergens, consistent with the theory that the human IgE-eosinophil 
      immune response to common allergens is a direct consequence of stimulation by 
      parasitic organisms.
FAU - Bielory, Brett Phillip
AU  - Bielory BP
AD  - Department of Medicine, Overlook Hospital, Summit, NJ, USA.
FAU - Mainardi, Timothy
AU  - Mainardi T
FAU - Rottem, Menachem
AU  - Rottem M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 0 (Antigens, Helminth)
RN  - 0 (Antigens, Plant)
RN  - 0 (Epitopes)
RN  - 0 (Fel d 2 allergen, Felis domesticus)
RN  - 0 (Insect Proteins)
RN  - 0 (Particulate Matter)
RN  - 0 (Serum Albumin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Allergens/chemistry/genetics/*immunology
MH  - Animals
MH  - Antigens, Helminth/chemistry/genetics/*immunology
MH  - Antigens, Plant/genetics/immunology
MH  - *Biological Evolution
MH  - Cats
MH  - Computational Biology
MH  - Conserved Sequence/genetics/immunology
MH  - Cross Reactions
MH  - Epitopes/chemistry/genetics/immunology
MH  - Helminthiasis/*immunology
MH  - Helminths/immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunity
MH  - Immunoglobulin E/immunology
MH  - Insect Proteins/genetics/immunology
MH  - Models, Immunological
MH  - Particulate Matter/immunology
MH  - Phosphopyruvate Hydratase/genetics/immunology
MH  - Plants/immunology
MH  - Plasmodium falciparum/immunology
MH  - Protein Structure, Tertiary/genetics
MH  - Sequence Homology, Amino Acid
MH  - Serum Albumin/genetics/immunology
EDAT- 2013/02/15 06:00
MHDA- 2013/08/07 06:00
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.2500/aap.2013.34.3616 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2013 Jan-Feb;34(1):93-102. doi: 10.2500/aap.2013.34.3616.