PMID- 23407231
OWN - NLM
STAT- MEDLINE
DCOM- 20130726
LR  - 20161125
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 17
IP  - 3
DP  - 2013 Mar
TI  - Sarcoidosis-associated pulmonary hypertension in patients with near-normal lung 
      function.
PG  - 406-11
LID - 10.5588/ijtld.12.0428 [doi]
AB  - SETTING: Tertiary care medical centre in Israel. BACKGROUND: Pulmonary 
      hypertension (PH) is a predictor of poor outcome in patients with sarcoidosis. 
      Early diagnosis may improve outcome. OBJECTIVE: To determine factors that might 
      contribute to the early diagnosis of PH in sarcoidosis patients with near normal 
      lung function tests. DESIGN: Retrospective patient review. METHODS: Data from 127 
      patients with sarcoidosis and near normal lung function tests (forced vital 
      capacity > 70%, forced expiratory volume in 1 second > 70% and diffusion capacity 
      of carbon monoxide [D(LCO)] > 60%), who underwent high resolution computed 
      tomography (HRCT) scan, the 6-minute walk distance (6MWD) test and echocardiogram 
      were analysed. Demographic, clinical and HRCT findings were compared between 
      patients with and those without PH. RESULTS: Thirty-six patients (28.3%) had PH. 
      Patients with PH tended to have lower D(LCO) (68% +/- 8 vs. 75% +/- 17, P = 0.038), 
      6MWD (308 m +/- 106 vs. 486 m +/- 99, P = 0.009) and exercise saturation (91 +/- 4 vs. 
      95 +/- 3, P = 0.0001) compared to those without PH. HRCT patterns in PH showed 
      higher frequencies of interstitial thickening (P = 0.004), ground glass 
      appearance (P = 0.01) and fibrosis (P = 0.032). In logistic regression, only 6MWD 
      was predictive of PH (P = 0.005, 95%CI 0.970-0.995). CONCLUSION: Physiological 
      and radiographic characteristics appeared to differentiate patients with PH from 
      those without. Physicians should be aware of PH in patients with sarcoidosis, 
      even in those with near normal lung function.
FAU - Maimon, N
AU  - Maimon N
AD  - Pulmonary Institute, Soroka University Medical Center, Beer Sheva, Israel.
FAU - Salz, L
AU  - Salz L
FAU - Shershevsky, Y
AU  - Shershevsky Y
FAU - Matveychuk, A
AU  - Matveychuk A
FAU - Guber, A
AU  - Guber A
FAU - Shitrit, D
AU  - Shitrit D
LA  - eng
PT  - Journal Article
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal 
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chi-Square Distribution
MH  - Early Diagnosis
MH  - Echocardiography, Doppler
MH  - Exercise Test
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Hypertension, Pulmonary/diagnosis/*etiology/physiopathology
MH  - Israel
MH  - Logistic Models
MH  - Lung/diagnostic imaging/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Pulmonary Diffusing Capacity
MH  - Retrospective Studies
MH  - Sarcoidosis, Pulmonary/*complications/diagnosis/physiopathology
MH  - Tertiary Care Centers
MH  - Tomography, X-Ray Computed
MH  - Vital Capacity
EDAT- 2013/02/15 06:00
MHDA- 2013/07/28 06:00
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2013/07/28 06:00 [medline]
AID - 10.5588/ijtld.12.0428 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2013 Mar;17(3):406-11. doi: 10.5588/ijtld.12.0428.