PMID- 23408092
OWN - NLM
STAT- MEDLINE
DCOM- 20140212
LR  - 20221207
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Print)
IS  - 0960-8923 (Linking)
VI  - 23
IP  - 7
DP  - 2013 Jul
TI  - Sagittal abdominal diameter and visceral adiposity: correlates of beta-cell 
      function and dysglycemia in severely obese women.
PG  - 874-81
LID - 10.1007/s11695-013-0874-6 [doi]
AB  - BACKGROUND: In the context of increasing obesity prevalence, the relationship 
      between large visceral adipose tissue (VAT) volumes and type 2 diabetes mellitus 
      (T2DM) is unclear. In a clinical sample of severely obese women (mean body mass 
      index [BMI], 46 kg/m(2)) with fasting normoglycemia (n = 40) or dysglycemia 
      (impaired fasting glucose + diabetes; n = 20), we sought to determine the 
      usefulness of anthropometric correlates of VAT and associations with dysglycemia. 
      METHODS: VAT volume was estimated using multi-slice computer tomography; 
      anthropometric surrogates included sagittal abdominal diameter (SAD), waist 
      circumference (WC) and BMI. Insulin sensitivity (Si), and beta-cell dysfunction, 
      measured by insulin secretion (AIRg) and the disposition index (DI), were 
      determined by frequently sampled intravenous glucose tolerance test. RESULTS: 
      Compared to fasting normoglycemic women, individuals with dysglycemia had greater 
      VAT (P < 0.001) and SAD (P = 0.04), but BMI, total adiposity and Si were similar. 
      VAT was inversely associated with AIRg and DI after controlling for ancestry, Si, 
      and total adiposity (standardized beta, -0.32 and -0.34, both P < 0.05). In 
      addition, SAD (beta = 0.41, P = 0.02) was found to be a better estimate of VAT 
      volume than WC (beta = 0.32, P = 0.08) after controlling for covariates. Receiver 
      operating characteristic analysis showed that VAT volume, followed by SAD, 
      outperformed WC and BMI in identifying dysglycemic participants. CONCLUSIONS: 
      Increasing VAT is associated with beta-cell dysfunction and dysglycemia in very 
      obese women. In the presence of severe obesity, SAD is a simple surrogate of VAT, 
      and an indicator of glucose dysregulation.
FAU - Gletsu-Miller, Nana
AU  - Gletsu-Miller N
AD  - Department of Nutrition Sciences, Purdue University, 700 W. State Street, Stone 
      Hall, West Lafayette, IN 47907, USA. ngletsum@purdue.edu
FAU - Kahn, Henry S
AU  - Kahn HS
FAU - Gasevic, Danijela
AU  - Gasevic D
FAU - Liang, Zhe
AU  - Liang Z
FAU - Frediani, Jennifer K
AU  - Frediani JK
FAU - Torres, William E
AU  - Torres WE
FAU - Ziegler, Thomas R
AU  - Ziegler TR
FAU - Phillips, Lawrence S
AU  - Phillips LS
FAU - Lin, Edward
AU  - Lin E
LA  - eng
GR  - R21 DK075745/DK/NIDDK NIH HHS/United States
GR  - TL1 TR000456/TR/NCATS NIH HHS/United States
GR  - R21 DK 075745/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - R18 DK066204/DK/NIDDK NIH HHS/United States
GR  - R03 DK067167/DK/NIDDK NIH HHS/United States
GR  - K24 RR023356/RR/NCRR NIH HHS/United States
GR  - UL1 RR025008/RR/NCRR NIH HHS/United States
GR  - M01 RR00039/RR/NCRR NIH HHS/United States
GR  - K24 DK096574/DK/NIDDK NIH HHS/United States
GR  - M01 RR000039/RR/NCRR NIH HHS/United States
GR  - DK066204/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Female
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/*metabolism
MH  - Intra-Abdominal Fat/metabolism/*pathology
MH  - Longitudinal Studies
MH  - Multidetector Computed Tomography
MH  - Obesity, Morbid/blood/complications/epidemiology/*metabolism/*pathology
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - *Sagittal Abdominal Diameter
MH  - United States/epidemiology
MH  - Waist Circumference
PMC - PMC3750719
MID - NIHMS496780
COIS- Conflict of interest No conflict of interest
EDAT- 2013/02/15 06:00
MHDA- 2014/02/13 06:00
PMCR- 2013/08/23
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2014/02/13 06:00 [medline]
PHST- 2013/08/23 00:00 [pmc-release]
AID - 10.1007/s11695-013-0874-6 [doi]
PST - ppublish
SO  - Obes Surg. 2013 Jul;23(7):874-81. doi: 10.1007/s11695-013-0874-6.