PMID- 23408162
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130215
LR  - 20211021
IS  - 2008-2835 (Print)
IS  - 2008-4625 (Electronic)
IS  - 2008-2835 (Linking)
VI  - 1
IP  - 3
DP  - 2009 Oct
TI  - Lack of Association between Tumor Necrosis Factor-alpha -308 G/A Polymorphism and 
      Risk of Developing Late-Onset Alzheimer's Disease in an Iranian Population.
PG  - 193-7
AB  - Late-onset Alzheimer's Disease (LOAD) is a neurodegenerative disorder and the 
      most common form of dementia affecting people over 65 years old. Alzheimer's 
      disease is a complex disease with multi-factorial etiology. Inflammation has been 
      approved to have an important role in the pathogenesis of Alzheimer's disease 
      (AD). TNF-alpha is a main pro-inflammatory cytokine that plays an essential role in 
      initiation and regulation of inflammatory responses. Several studies have shown 
      the probable association of polymorphism at TNF-alpha gene's promoter with AD 
      pathogenesis. This study was performed to determine whether this polymorphism 
      contributes to the risk for late-onset Alzheimer's disease (LOAD) in Iranian 
      population. One hundred and forty AD patients and 158 healthy controls were 
      recruited in the study. Following extraction of genomic DNA, using PCR/RFLP 
      methods the genotype and allele frequencies were determined in case and control 
      subjects. The statistical analysis showed no significant difference in the allele 
      and genotype frequencies due to this polymorphism between the two groups. Also 
      after stratifying the subjects by their APOE-varepsilon4 status, no significant 
      association was observed. Our results suggest that Tumor necrosis factor-alpha 
      (TNF-alpha)-308 G/A is not a risk or protective factor for late-onset Alzheimer's 
      disease in Iranian population. However, to confirm these results further study 
      with a bigger sample size may be required.
FAU - Manoochehri, Mehdi
AU  - Manoochehri M
AD  - Genetics Research Center, University of Social Welfare and Rehabilitation 
      Sciences, Tehran, Iran.
FAU - Kamali, Koorosh
AU  - Kamali K
FAU - Rahgozar, Mehdi
AU  - Rahgozar M
FAU - Ohadi, Mina
AU  - Ohadi M
FAU - Farrokhi, Homa
AU  - Farrokhi H
FAU - Khorshid, Hamid Reza Khorram
AU  - Khorshid HR
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Avicenna J Med Biotechnol
JT  - Avicenna journal of medical biotechnology
JID - 101511065
PMC - PMC3558134
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Gene
OT  - Genetic association study
OT  - Polymorphism
OT  - Population
OT  - TNF-alpha
EDAT- 2009/10/01 00:00
MHDA- 2009/10/01 00:01
PMCR- 2009/10/01
CRDT- 2013/02/15 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2009/12/09 00:00 [accepted]
PHST- 2013/02/15 06:00 [entrez]
PHST- 2009/10/01 00:00 [pubmed]
PHST- 2009/10/01 00:01 [medline]
PHST- 2009/10/01 00:00 [pmc-release]
AID - AJMB-1-193 [pii]
PST - ppublish
SO  - Avicenna J Med Biotechnol. 2009 Oct;1(3):193-7.