PMID- 23408348
OWN - NLM
STAT- MEDLINE
DCOM- 20140227
LR  - 20211021
IS  - 1468-3288 (Electronic)
IS  - 0017-5749 (Print)
IS  - 0017-5749 (Linking)
VI  - 63
IP  - 2
DP  - 2014 Feb
TI  - Visceral abdominal obesity measured by CT scan is associated with an increased 
      risk of Barrett's oesophagus: a case-control study.
PG  - 220-9
LID - 10.1136/gutjnl-2012-304189 [doi]
AB  - OBJECTIVE: Abdominal obesity has been associated with increased risk of Barrett's 
      oesophagus (BE) but the underlying mechanism is unclear. We examined the 
      association between visceral adipose tissue (VAT) and subcutaneous adipose tissue 
      (SAT) and the risk of BE. DESIGN: A case-control study among eligible patients 
      scheduled for elective oesophagastroduodenoscopy (EGD) and in a sample of 
      patients eligible for screening colonoscopy recruited at the primary care clinic. 
      All cases with definitive BE and a random sample of controls without BE were 
      invited to undergo standardised mid-abdomen non-contrast computerised axial 
      tomography images, which were analysed by semiautomated image segmentation 
      software. The effect of VAT and SAT surface areas and their ratio (VAT to SAT) on 
      BE were analysed in logistic regression models. RESULTS: A total of 173 BE cases, 
      343 colonoscopy controls and 172 endoscopy controls underwent study EGD and CT 
      scan. Participants with BE were more than twice as likely to be in the highest 
      tertile of VAT to SAT ratio (OR: 2.42 (1.51 to 3.88) and adjusted OR 1.47 (0.88 
      to 2.45)) than colonoscopy controls, especially for those long (>/=3 cm) segment BE 
      (3.42 (1.67 to 7.01) and adjusted OR 1.93 (0.92 to 4.09)) and for white men 
      (adjusted OR 2.12 (1.15 to 3.90)). Adjustment for gastroesophageal reflux disease 
      (GERD) symptoms and proton pump inhibitors (PPI) use attenuated this association, 
      but there was a significant increase in BE risk even in the absence of GERD or 
      PPI use. CONCLUSIONS: Large amount of visceral abdominal fat relative to 
      subcutaneous fat is associated with a significant increase in the risk of BE. 
      GERD may mediate some but not all of this association.
FAU - El-Serag, Hashem B
AU  - El-Serag HB
AD  - Houston VA HSR&D Center of Excellence Section, Michael E. DeBakey VA Medical 
      Center and Baylor College of Medicine, , Houston, Texas, USA.
FAU - Hashmi, Ali
AU  - Hashmi A
FAU - Garcia, Jose
AU  - Garcia J
FAU - Richardson, Peter
AU  - Richardson P
FAU - Alsarraj, Abeer
AU  - Alsarraj A
FAU - Fitzgerald, Stephanie
AU  - Fitzgerald S
FAU - Vela, Marcelo
AU  - Vela M
FAU - Shaib, Yasser
AU  - Shaib Y
FAU - Abraham, Neena S
AU  - Abraham NS
FAU - Velez, Maria
AU  - Velez M
FAU - Cole, Rhonda
AU  - Cole R
FAU - Rodriguez, Margot B
AU  - Rodriguez MB
FAU - Anand, Bhupinderjit
AU  - Anand B
FAU - Graham, David Y
AU  - Graham DY
FAU - Kramer, Jennifer R
AU  - Kramer JR
LA  - eng
GR  - P30 DK056338/DK/NIDDK NIH HHS/United States
GR  - K24-04-107/PHS HHS/United States
GR  - DK58338/DK/NIDDK NIH HHS/United States
GR  - R01 116845/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130213
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
SB  - IM
MH  - Aged
MH  - Barrett Esophagus/diagnostic imaging/*etiology
MH  - Case-Control Studies
MH  - Female
MH  - Gastroesophageal Reflux/complications/diagnostic imaging
MH  - Humans
MH  - Intra-Abdominal Fat/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/*complications/diagnostic imaging
MH  - Risk Factors
MH  - Subcutaneous Fat/*diagnostic imaging
MH  - Texas
MH  - *Tomography, X-Ray Computed
PMC - PMC3976427
MID - NIHMS564470
OTO - NOTNLM
OT  - Epidemiology
OT  - Obesity
COIS- Competing interests None.
EDAT- 2013/02/15 06:00
MHDA- 2014/02/28 06:00
PMCR- 2015/02/01
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2014/02/28 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - gutjnl-2012-304189 [pii]
AID - 10.1136/gutjnl-2012-304189 [doi]
PST - ppublish
SO  - Gut. 2014 Feb;63(2):220-9. doi: 10.1136/gutjnl-2012-304189. Epub 2013 Feb 13.