PMID- 23408741
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 5
IP  - 3
DP  - 2013 Mar
TI  - Protective effects of Quercus salicina on alloxan-induced oxidative stress in 
      HIT-T15 pancreatic beta cells.
PG  - 947-951
AB  - The present study was designed to investigate the protective effect of hot water 
      extracts from Quercus salicina leaves (QSWE) on alloxan-induced oxidative stress 
      in HIT-T15 Syrian hamster pancreatic insulinoma cells. The HIT-T15 cells were 
      treated with alloxan (1 mM) for 1 h and then co-incubated with the QSWE for 24 h. 
      Alloxan significantly decreased the viability of the HIT-T15 cells (P<0.05). QSWE 
      did not exhibit significantly cytotoxic effects and increased the viability of 
      the HIT-T15 cells in a concentration-dependent manner. To further investigate the 
      protective effects of QSWE on alloxan-induced oxidative stress in HIT-T15 cells, 
      the cellular levels of reactive oxygen species (ROS), lipid peroxidation and 
      endogenous antioxidant enzymes, including catalase (CAT), superoxide dismutase 
      (SOD) and glutathione peroxidase (GSH-px), were analyzed. QSWE decreased the 
      intracellular levels of ROS and lipid peroxidation and increased the activity of 
      antioxidant enzymes. These results suggest that QSWE exerted cytoprotective 
      activity against alloxan-induced oxidative stress in HIT-T15 cells through the 
      inhibition of lipid peroxidation, reduction of ROS levels and stimulation of 
      antioxidant enzyme activity. In addition, QSWE also increased the insulin 
      secretion activity of the alloxan-treated HIT-T15 cells.
FAU - Song, Jia-LE
AU  - Song JL
AD  - Department of Food Science and Nutrition, Pusan National University, Busan 
      609-735, Republic of Korea ;
FAU - Zhao, Xin
AU  - Zhao X
FAU - Wang, Qiang
AU  - Wang Q
LA  - eng
PT  - Journal Article
DEP - 20130107
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3570244
OTO - NOTNLM
OT  - Quercus salicina
OT  - cell viability
OT  - insulin secretion
OT  - pancreatic beta cells
OT  - reactive oxygen species
EDAT- 2013/02/15 06:00
MHDA- 2013/02/15 06:01
PMCR- 2013/01/07
CRDT- 2013/02/15 06:00
PHST- 2012/11/28 00:00 [received]
PHST- 2013/01/02 00:00 [accepted]
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2013/02/15 06:01 [medline]
PHST- 2013/01/07 00:00 [pmc-release]
AID - etm-05-03-0947 [pii]
AID - 10.3892/etm.2013.885 [doi]
PST - ppublish
SO  - Exp Ther Med. 2013 Mar;5(3):947-951. doi: 10.3892/etm.2013.885. Epub 2013 Jan 7.