PMID- 23408772
OWN - NLM
STAT- MEDLINE
DCOM- 20140506
LR  - 20221207
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 21
IP  - 10
DP  - 2013 Oct
TI  - Abdominal myosteatosis is independently associated with hyperinsulinemia and 
      insulin resistance among older men without diabetes.
PG  - 2118-25
LID - 10.1002/oby.20346 [doi]
AB  - OBJECTIVE: Skeletal muscle adipose tissue (AT) infiltration (myosteatosis) 
      increases with aging and may contribute to the development of Type 2 diabetes 
      mellitus (T2DM). It remains unclear if myosteatosis is associated to glucose and 
      insulin homeostasis independent of total and central adiposity. DESIGN AND 
      METHODS: The association between intermuscular AT (IMAT) in the abdominal 
      skeletal muscles (total, paraspinal, and psoas) and fasting serum glucose, 
      insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) in 393 
      nondiabetic Caucasian men aged 65+ was evaluated. Abdominal IMAT, visceral AT 
      (VAT), and subcutaneous AT (SAT) (cm(3) ) were measured by quantitative computed 
      tomography at the L4-L5 intervertebral space. RESULTS: In age, study site, 
      height, and muscle volume adjusted regression analyses, total abdominal and psoas 
      (but not paraspinal) IMAT were positively associated with glucose, insulin, and 
      HOMA-IR (all P < 0.003). The associations between total abdominal and psoas IMAT 
      and insulin and HOMA-IR remained significant after further adjusting for 
      lifestyle factors, as well as duel-energy x-ray absorptiometry (DXA) measured 
      total body fat, VAT, or SAT in separate models (all P < 0.009). CONCLUSIONS: A 
      previously unreported, independent association between abdominal myosteatosis and 
      hyperinsulinemia and insulin resistance among older Caucasian men was indicated. 
      These associations may be specific for particular abdominal muscle depots, 
      illustrating the potential importance of separately studying specific muscle 
      groups.
CI  - Copyright (c) 2013 The Obesity Society.
FAU - Miljkovic, Iva
AU  - Miljkovic I
AD  - Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, 
      USA.
FAU - Cauley, Jane A
AU  - Cauley JA
FAU - Wang, Patty Y
AU  - Wang PY
FAU - Holton, Kathleen F
AU  - Holton KF
FAU - Lee, Christine G
AU  - Lee CG
FAU - Sheu, Yahtyng
AU  - Sheu Y
FAU - Barrett-Connor, Elizabeth
AU  - Barrett-Connor E
FAU - Hoffman, Andrew R
AU  - Hoffman AR
FAU - Lewis, Cora B
AU  - Lewis CB
FAU - Orwoll, Eric S
AU  - Orwoll ES
FAU - Stefanick, Marcia L
AU  - Stefanick ML
FAU - Strotmeyer, Elsa S
AU  - Strotmeyer ES
FAU - Marshall, Lynn M
AU  - Marshall LM
CN  - Osteoporotic Fractures in Men (MrOS) Research Group
LA  - eng
GR  - U01 AR45632/AR/NIAMS NIH HHS/United States
GR  - U01 AR45647/AR/NIAMS NIH HHS/United States
GR  - U01 AR45614/AR/NIAMS NIH HHS/United States
GR  - U01 AR45583/AR/NIAMS NIH HHS/United States
GR  - P60 AR05473101/AR/NIAMS NIH HHS/United States
GR  - U01 AR045614/AR/NIAMS NIH HHS/United States
GR  - U01 AR45654/AR/NIAMS NIH HHS/United States
GR  - K01 DK083029/DK/NIDDK NIH HHS/United States
GR  - U01 AR045654/AR/NIAMS NIH HHS/United States
GR  - U01 AG042168/AG/NIA NIH HHS/United States
GR  - U01-AG027810/AG/NIA NIH HHS/United States
GR  - U01 AR045583/AR/NIAMS NIH HHS/United States
GR  - R01 HL084183/HL/NHLBI NIH HHS/United States
GR  - U01 AR045647/AR/NIAMS NIH HHS/United States
GR  - U01 AR45580/AR/NIAMS NIH HHS/United States
GR  - K01DK08302/DK/NIDDK NIH HHS/United States
GR  - U01 AG027810/AG/NIA NIH HHS/United States
GR  - UL1 RR024140/RR/NCRR NIH HHS/United States
GR  - U01 AR045580/AR/NIAMS NIH HHS/United States
GR  - U01 AG18197/AG/NIA NIH HHS/United States
GR  - U01 AG018197/AG/NIA NIH HHS/United States
GR  - R21 DK066224/DK/NIDDK NIH HHS/United States
GR  - U01 AR066160/AR/NIAMS NIH HHS/United States
GR  - U01 AR045632/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130529
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adiposity/physiology
MH  - Aged
MH  - Aging/*physiology
MH  - Blood Glucose/metabolism
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2
MH  - Fasting
MH  - Homeostasis
MH  - Humans
MH  - Hyperinsulinism/*physiopathology
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Intra-Abdominal Fat/metabolism/physiopathology
MH  - Male
MH  - Osteoporotic Fractures
MH  - Prospective Studies
MH  - Psoas Muscles/*physiopathology
MH  - Subcutaneous Fat/metabolism/physiopathology
MH  - United States
MH  - White People
PMC - PMC3661705
MID - NIHMS434492
COIS- Competing interests: The authors have no competing interests.
EDAT- 2013/02/15 06:00
MHDA- 2014/05/07 06:00
PMCR- 2014/04/01
CRDT- 2013/02/15 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2012/12/13 00:00 [accepted]
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2014/05/07 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.1002/oby.20346 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2013 Oct;21(10):2118-25. doi: 10.1002/oby.20346. Epub 
      2013 May 29.