PMID- 23408849
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20130417
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 207
IP  - 10
DP  - 2013 May 15
TI  - Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is 
      consistent with transmission of a chromosomally integrated reactivated virus.
PG  - 1585-9
LID - 10.1093/infdis/jit060 [doi]
AB  - The majority of human herpesvirus 6 (HHV-6) congenital infections (86%) originate 
      from germ line transmission of chromosomally integrated HHV-6 (ciHHV-6). To 
      determine whether transplacentally acquired HHV-6 could derive from the 
      transmission of reactivated maternal ciHHV-6, we identified mother-infant pairs 
      in which infants had proven transplacentally acquired HHV-6 and mothers had 
      documented ciHHV-6, and we sequenced and compared the HHV-6 gB gene sequences for 
      each pair. Our data indicate that the gB gene sequence found in each cord blood 
      specimen was identical to that of the corresponding mother but divergent from 
      that of other known HHV-6 isolates. These results are consistent with 
      transplacentally acquired HHV-6 originating from the transmission of reactivated 
      ciHHV-6.
FAU - Gravel, Annie
AU  - Gravel A
AD  - Division of Infectious Diseases and Immunity, Centre Hospitalier Universitaire de 
      Quebec, Canada.
FAU - Hall, Caroline Breese
AU  - Hall CB
FAU - Flamand, Louis
AU  - Flamand L
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130213
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (DNA, Viral)
RN  - 0 (Glycoproteins)
SB  - IM
MH  - Chromosomes, Human/genetics/*virology
MH  - DNA, Viral/genetics
MH  - Female
MH  - Genes, Viral
MH  - Glycoproteins/genetics/metabolism
MH  - Herpesvirus 6, Human/*genetics/isolation & purification
MH  - Humans
MH  - Infant
MH  - *Infectious Disease Transmission, Vertical
MH  - Polymorphism, Genetic
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*virology
MH  - Sequence Analysis, DNA
MH  - Viral Load
MH  - *Virus Integration
EDAT- 2013/02/15 06:00
MHDA- 2013/06/12 06:00
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - jit060 [pii]
AID - 10.1093/infdis/jit060 [doi]
PST - ppublish
SO  - J Infect Dis. 2013 May 15;207(10):1585-9. doi: 10.1093/infdis/jit060. Epub 2013 
      Feb 13.