PMID- 23410698
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20220318
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
VI  - 77
IP  - 3
DP  - 2013 Mar
TI  - Adverse events requiring hospitalization within 30 days after outpatient 
      screening and nonscreening colonoscopies.
PG  - 419-29
LID - S0016-5107(12)02864-7 [pii]
LID - 10.1016/j.gie.2012.10.028 [doi]
AB  - BACKGROUND: The incidence of adverse events (AEs) is a crucial factor when 
      colonoscopy is considered for mass screening, but few studies have addressed 
      delayed and non-GI AEs. OBJECTIVES: To investigate the risk of AEs requiring 
      hospitalization after screening and nonscreening colonoscopies compared with 
      control subjects who did not undergo colonoscopy. DESIGN: Retrospective matched 
      cohort. SETTING: Statutory health insurance fund in Germany. PATIENTS: A total of 
      33,086 individuals who underwent colonoscopy as an outpatient (8658 screening, 
      24,428 nonscreening) and 33,086 matched controls who did not undergo colonoscopy. 
      INTERVENTIONS: Outpatient screening and nonscreening colonoscopies. MAIN OUTCOMES 
      MEASUREMENTS: Risk of AEs (perforation, bleeding, myocardial infarction, stroke, 
      splenic injury, and others) requiring hospitalization within 30 days after 
      colonoscopy/index date and risk differences between the group that underwent 
      colonoscopy and the group that did not. RESULTS: The incidence of perforation was 
      0.8 (95% confidence interval [CI], 0.3-1.7) and 0.7 (95% CI, 0.4-1.1) per 1000 
      screening and nonscreening colonoscopies, respectively. Hospitalizations because 
      of bleeding occurred in 0.5 (95% CI, 0.1-1.2) and 1.1 (95% CI, 0.8-1.7) per 1000 
      screening and nonscreening colonoscopies, respectively. The incidence of 
      myocardial infarction, stroke, and other non-GI AEs was similar in colonoscopy 
      and control groups. No splenic injury was observed. Those with AEs generally had 
      a higher mean age and comorbidity rate than the overall study population. 
      LIMITATIONS: The analysis relies on health insurance claims data. CONCLUSIONS: 
      This study provides further evidence of the safety of colonoscopy in routine 
      practice with regard to delayed and non-GI AEs. Hospitalizations because of the 
      investigated AEs were uncommon or rare for both screening and nonscreening 
      colonoscopies.
CI  - Copyright (c) 2013 American Society for Gastrointestinal Endoscopy. Published by 
      Mosby, Inc. All rights reserved.
FAU - Stock, Christian
AU  - Stock C
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research 
      Center (DKFZ), Heidelberg, Germany.
FAU - Ihle, Peter
AU  - Ihle P
FAU - Sieg, Andreas
AU  - Sieg A
FAU - Schubert, Ingrid
AU  - Schubert I
FAU - Hoffmeister, Michael
AU  - Hoffmeister M
FAU - Brenner, Hermann
AU  - Brenner H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Ambulatory Care/statistics & numerical data
MH  - Case-Control Studies
MH  - Colonoscopy/*adverse effects/statistics & numerical data
MH  - Female
MH  - Germany/epidemiology
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Intestinal Perforation/*epidemiology/etiology
MH  - Male
MH  - Mass Screening/*adverse effects/statistics & numerical data
MH  - Middle Aged
MH  - Myocardial Infarction/epidemiology
MH  - Postoperative Hemorrhage/*epidemiology/etiology
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Stroke/epidemiology
MH  - Time Factors
MH  - Young Adult
EDAT- 2013/02/16 06:00
MHDA- 2013/09/14 06:00
CRDT- 2013/02/16 06:00
PHST- 2012/05/06 00:00 [received]
PHST- 2012/10/29 00:00 [accepted]
PHST- 2013/02/16 06:00 [entrez]
PHST- 2013/02/16 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
AID - S0016-5107(12)02864-7 [pii]
AID - 10.1016/j.gie.2012.10.028 [doi]
PST - ppublish
SO  - Gastrointest Endosc. 2013 Mar;77(3):419-29. doi: 10.1016/j.gie.2012.10.028.