PMID- 23411880
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20220410
IS  - 2168-6173 (Electronic)
IS  - 2168-6165 (Linking)
VI  - 131
IP  - 2
DP  - 2013 Feb
TI  - Association of inflammatory factors with macular edema in branch retinal vein 
      occlusion.
PG  - 160-5
LID - 10.1001/2013.jamaophthalmol.228 [doi]
AB  - OBJECTIVE: To evaluate the association between vitreous fluid levels of 
      inflammatory factors and macular edema in patients with branch retinal vein 
      occlusion (BRVO). METHODS: In 39 patients with BRVO and macular edema and 21 
      individuals with idiopathic macular hole (MH) serving as controls, vitreous fluid 
      samples were obtained during vitreoretinal surgery, and the levels of vascular 
      endothelial growth factor (VEGF), soluble VEGF receptor 2 (sVEGFR-2), soluble 
      intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), monocyte 
      chemotactic protein 1 (MCP-1), pentraxin 3 (PTX3), and pigment epithelium-derived 
      factor (PEDF) were measured by enzyme-linked immunosorbent assay. Macular edema 
      was examined by optical coherence tomography. RESULTS: Vitreous fluid levels of 
      sVEGFR-2, VEGF, sICAM-1, IL-6, MCP-1, and PTX3 were significantly higher in the 
      patients with BRVO than in those with MH; however, the PEDF level was 
      significantly lower in the BRVO group. Vitreous fluid levels of all 7 factors 
      were significantly correlated with the retinal thickness at the central fovea. 
      There were also significant correlations of sVEGFR-2 with sICAM-1, IL-6, MCP-1, 
      and PTX3 but no correlation with VEGF. However, there were significant 
      correlations of VEGF with sICAM-1, IL-6, MCP-1, and PEDF in the BRVO group. 
      CONCLUSIONS: Vitreous fluid levels of sVEGFR-2, VEGF, sICAM-1, IL-6, MCP-1, PTX3, 
      and PEDF are strongly correlated with retinal vascular permeability and the 
      severity of macular edema in patients with BRVO. These findings may be useful for 
      understanding macular edema and developing new treatments for BRVO.
FAU - Noma, Hidetaka
AU  - Noma H
AD  - Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical 
      University, Tokyo, Japan. noma-hide@umin.ac.jp
FAU - Mimura, Tatsuya
AU  - Mimura T
FAU - Eguchi, Shuichiro
AU  - Eguchi S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAMA Ophthalmol
JT  - JAMA ophthalmology
JID - 101589539
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Eye Proteins)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Serpins)
RN  - 0 (Serum Amyloid P-Component)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (pigment epithelium-derived factor)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 148591-49-5 (PTX3 protein)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
SB  - IM
MH  - Aged
MH  - Biomarkers/*metabolism
MH  - C-Reactive Protein/metabolism
MH  - Capillary Permeability
MH  - Case-Control Studies
MH  - Chemokine CCL2/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Eye Proteins/metabolism
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Inflammation Mediators/*metabolism
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Interleukin-6/metabolism
MH  - Macular Edema/*metabolism/surgery
MH  - Male
MH  - Nerve Growth Factors/metabolism
MH  - Retinal Vein/metabolism
MH  - Retinal Vein Occlusion/*metabolism/surgery
MH  - Retrospective Studies
MH  - Serpins/metabolism
MH  - Serum Amyloid P-Component/metabolism
MH  - Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - Vascular Endothelial Growth Factor Receptor-2/metabolism
MH  - Vitrectomy
MH  - Vitreous Body/*metabolism
EDAT- 2013/02/16 06:00
MHDA- 2013/04/20 06:00
CRDT- 2013/02/16 06:00
PHST- 2013/02/16 06:00 [entrez]
PHST- 2013/02/16 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - 1653286 [pii]
AID - 10.1001/2013.jamaophthalmol.228 [doi]
PST - ppublish
SO  - JAMA Ophthalmol. 2013 Feb;131(2):160-5. doi: 10.1001/2013.jamaophthalmol.228.