PMID- 2341288
OWN - NLM
STAT- MEDLINE
DCOM- 19900626
LR  - 20191029
IS  - 0883-2897 (Print)
IS  - 0883-2897 (Linking)
VI  - 17
IP  - 3
DP  - 1990
TI  - Conjugation of a monoclonal antibody with a DTPA modified random copolymer of 
      hydroxyethyl methylacrylate and methyl methacrylate.
PG  - 321-9
AB  - A new approach for covalent coupling diethylenetriaminepentaacetic acid (DTPA) 
      molecules to a partially reduced monoclonal antibody utilizes a malemide modified 
      copolymer of hydroxyethyl methylacrylate and methyl methacrylate (DTPA copolymer) 
      prepared by the group transfer polymerization (GTP) method. An average of 6 DTPA 
      molecules were incorporated per mol maleimeide DTPA copolymer and 1.5 mol 
      maleimide DTPA copolymer per mol antibody. Maleimide DTPA copolymer modified 
      antibody was intramolecularly cross-linked, reduced immunoactivity and had a high 
      in vivo liver uptake.
FAU - Comeau, R D
AU  - Comeau RD
AD  - Seragen Inc., Hopkinton, MA 01748.
FAU - Liberatore, F A
AU  - Liberatore FA
FAU - Cocuzza, A J
AU  - Cocuzza AJ
FAU - Emond, G Y
AU  - Emond GY
FAU - Dicker, I B
AU  - Dicker IB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Rad Appl Instrum B
JT  - International journal of radiation applications and instrumentation. Part B, 
      Nuclear medicine and biology
JID - 8611098
RN  - 0 (Acrylates)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (DTPA copolymer)
RN  - 0 (Indium Radioisotopes)
RN  - 0 (Methacrylates)
RN  - 7A314HQM0I (Pentetic Acid)
SB  - IM
MH  - Acrylates/*chemical synthesis
MH  - Animals
MH  - *Antibodies, Monoclonal
MH  - Indium Radioisotopes
MH  - Isotope Labeling/methods
MH  - Methacrylates/*chemical synthesis/pharmacokinetics
MH  - Mice
MH  - Pentetic Acid/*chemical synthesis/pharmacokinetics
MH  - Tissue Distribution
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1016/0883-2897(90)90059-a [doi]
PST - ppublish
SO  - Int J Rad Appl Instrum B. 1990;17(3):321-9. doi: 10.1016/0883-2897(90)90059-a.