PMID- 23413874
OWN - NLM
STAT- MEDLINE
DCOM- 20150411
LR  - 20220331
IS  - 1600-0501 (Electronic)
IS  - 0905-7161 (Linking)
VI  - 25
IP  - 2
DP  - 2014 Feb
TI  - Dose-dependent effect of radiation on titanium implants: a quantitative study in 
      rabbits.
PG  - 260-5
LID - 10.1111/clr.12116 [doi]
AB  - OBJECTIVES: The aim of the study was to investigate the dose-dependent effect of 
      radiation on dental implant stability and osseointegration using a series of 
      quantitative analyses. MATERIAL AND METHODS: Six rabbits were randomly assigned 
      to 15 and 30 Gy radiation groups. Each rabbit received radiation at the tibial 
      and femoral metaphyseal region of left hind leg. The right leg was used as 
      control. Implant surgery was performed on tibial and femoral metaphyses after 1 
      week. Totally 24 implants were inserted. The animals were killed at postoperative 
      week four. Implant stability was measured using resonance frequency analysis. 
      Ratio of bone volume to total volume (BV/TV), rate of bone growth, and 
      bone-to-implant contact (BIC) were assessed using micro-computed tomography 
      (micro-CT), fluorochrome labeling analysis, and histomorphometric analysis, 
      respectively. RESULTS: After 4 weeks of healing, all implants were integrated (n 
      = 6). Implant stability was significantly compromised by 15 Gy (P = 0.010) and 30 
      Gy (P = 0.025) of radiation. Radiation decreased BV/TV, and the significant 
      effect was detected at the dose of 15 Gy (P = 0.008) and 30 Gy (P < 0.001). Bone 
      growth in osseointegration was impaired by radiation. In 15 Gy group, the 
      radiation side showed significant lower rate of bone growth than the control side 
      at week 3 (P = 0.001), while the undistinguishable signals on 30 Gy radiation 
      side suggested the low rate of new bone formation at each time point. 
      Histomorphological BIC had no significant difference between 15 Gy control side 
      and 15 Gy radiation side. 30 Gy radiation side showed a significantly lower BIC 
      than 30 Gy control side (P < 0.001) as well as 15 Gy radiation side (P < 0.001). 
      CONCLUSIONS: Implant stability and osseointegration were compromised by 
      radiation. Radiation compromised osseointegration in a dose-dependent manner.
CI  - (c) 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
FAU - Li, Jun Yuan
AU  - Li JY
AD  - Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong 
      Kong, China.
FAU - Pow, Edmond Ho Nang
AU  - Pow EH
FAU - Zheng, Li Wu
AU  - Zheng LW
FAU - Ma, Li
AU  - Ma L
FAU - Kwong, Dora Lai Wan
AU  - Kwong DL
FAU - Cheung, Lim Kwong
AU  - Cheung LK
LA  - eng
PT  - Journal Article
DEP - 20130218
PL  - Denmark
TA  - Clin Oral Implants Res
JT  - Clinical oral implants research
JID - 9105713
RN  - 0 (Dental Implants)
RN  - D1JT611TNE (Titanium)
MH  - Animals
MH  - *Dental Implants
MH  - *Dose-Response Relationship, Radiation
MH  - Femur/diagnostic imaging/*radiation effects/surgery
MH  - Implants, Experimental
MH  - Osseointegration/*radiation effects
MH  - Rabbits
MH  - Radiation Dosage
MH  - Random Allocation
MH  - Tibia/diagnostic imaging/*radiation effects/surgery
MH  - Titanium
MH  - X-Ray Microtomography
OTO - NOTNLM
OT  - animal experiments
OT  - biomaterials
OT  - bone-implant interactions
OT  - morphometric analysis
OT  - radiology
EDAT- 2013/02/19 06:00
MHDA- 2015/04/12 06:00
CRDT- 2013/02/19 06:00
PHST- 2012/12/22 00:00 [accepted]
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2015/04/12 06:00 [medline]
AID - 10.1111/clr.12116 [doi]
PST - ppublish
SO  - Clin Oral Implants Res. 2014 Feb;25(2):260-5. doi: 10.1111/clr.12116. Epub 2013 
      Feb 18.