PMID- 23416450
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20211021
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 16
IP  - 4
DP  - 2013 Apr
TI  - EGF transactivation of Trk receptors regulates the migration of newborn cortical 
      neurons.
PG  - 407-15
LID - 10.1038/nn.3333 [doi]
AB  - The development of neuronal networks in the neocortex depends on control 
      mechanisms for mitosis and migration that allow newborn neurons to find their 
      accurate position. Multiple mitogens, neurotrophic factors, guidance molecules 
      and their corresponding receptors are involved in this process, but the 
      mechanisms by which these signals are integrated are only poorly understood. We 
      found that TrkB and TrkC, the receptors for brain-derived neurotrophic factor 
      (BDNF) and neurotrophin-3 (NT-3), are activated by epidermal growth factor 
      receptor (EGFR) signaling rather than by BDNF or NT-3 in embryonic mouse cortical 
      precursor cells. This transactivation event regulated migration of early neuronal 
      cells to their final position in the developing cortex. Transactivation by EGF 
      led to membrane translocation of TrkB, promoting its signaling responsiveness. 
      Our results provide genetic evidence that TrkB and TrkC activation in early 
      cortical neurons do not depend on BDNF and NT-3, but instead on transactivation 
      by EGFR signaling.
FAU - Puehringer, Dirk
AU  - Puehringer D
AD  - Institute for Clinical Neurobiology, University of Wuerzburg, Wuerzburg, Germany.
FAU - Orel, Nadiya
AU  - Orel N
FAU - Luningschror, Patrick
AU  - Luningschror P
FAU - Subramanian, Narayan
AU  - Subramanian N
FAU - Herrmann, Thomas
AU  - Herrmann T
FAU - Chao, Moses V
AU  - Chao MV
FAU - Sendtner, Michael
AU  - Sendtner M
LA  - eng
GR  - R01 AG025970/AG/NIA NIH HHS/United States
GR  - R01 NS021072/NS/NINDS NIH HHS/United States
GR  - R56 NS021072/NS/NINDS NIH HHS/United States
GR  - NS21072-24/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130217
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Movement/*physiology
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology/metabolism
MH  - Epidermal Growth Factor/*physiology
MH  - Female
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neurons/metabolism
MH  - Pregnancy
MH  - Receptor, trkB/genetics/*metabolism
MH  - Receptor, trkC/genetics/*metabolism
MH  - Signal Transduction/physiology
MH  - Transcriptional Activation/*physiology
PMC - PMC4148818
MID - NIHMS615618
COIS- COMPETING FINANCIAL INTERESTS The authors declare no competing financial 
      interests.
EDAT- 2013/02/19 06:00
MHDA- 2013/05/23 06:00
PMCR- 2014/08/29
CRDT- 2013/02/19 06:00
PHST- 2012/07/31 00:00 [received]
PHST- 2013/01/17 00:00 [accepted]
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
PHST- 2014/08/29 00:00 [pmc-release]
AID - nn.3333 [pii]
AID - 10.1038/nn.3333 [doi]
PST - ppublish
SO  - Nat Neurosci. 2013 Apr;16(4):407-15. doi: 10.1038/nn.3333. Epub 2013 Feb 17.