PMID- 23416721
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20211203
IS  - 1473-6519 (Electronic)
IS  - 1363-1950 (Linking)
VI  - 16
IP  - 3
DP  - 2013 May
TI  - Placental regulation of fetal nutrient supply.
PG  - 292-7
LID - 10.1097/MCO.0b013e32835e3674 [doi]
AB  - PURPOSE OF REVIEW: Placental nutrient uptake and transfer may have a unique role, 
      as changes in trophoblast nutrient-sensing signaling pathways regulate cell 
      metabolism and may affect the fetal growth and health programming in the 
      offspring. RECENT FINDINGS: The functionality of the placenta could affect the 
      neonatal adiposity and the fetal levels of key nutrients such as long-chain 
      polyunsaturated fatty acids. Insulin, oxygen and amino acid concentrations may 
      regulate the mammalian target of rapamycin (mTOR) nutrient sensor in the human 
      placenta affecting trophoblast metabolism and nutrient delivery. SUMMARY: The 
      mechanisms involved in both placental uptake and transfer of macronutrients are 
      reviewed. Fatty acid, cholesterol and amino acid transport across the placenta 
      involves a complex system to ensure nutrient delivery to the growing fetus. The 
      placental glucose transfer is important for fetal macrosomia, but lipid 
      disturbances in both maternal and placental compartments may contribute to 
      neonatal fat accretion. Maternal insulin has little effect on the avidity of 
      glucose transport by the placenta, but may interfere in placental metabolism via 
      mTOR nutrient sensor. mTOR is a positive regulator of the amino acid carriers and 
      constitutes a critical link between maternal nutrient availability and fetal 
      growth, thereby influencing the long-term health of the fetus.
FAU - Larque, Elvira
AU  - Larque E
AD  - Department of Physiology, Faculty of Biology, University of Murcia, Murcia, 
      Spain. elvirada@um.es
FAU - Ruiz-Palacios, Maria
AU  - Ruiz-Palacios M
FAU - Koletzko, Berthold
AU  - Koletzko B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Clin Nutr Metab Care
JT  - Current opinion in clinical nutrition and metabolic care
JID - 9804399
RN  - 0 (Amino Acids)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Glucose Transport Proteins, Facilitative)
RN  - 0 (Insulin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Amino Acids/administration & dosage/pharmacokinetics
MH  - Biological Transport
MH  - Cholesterol/administration & dosage/pharmacokinetics
MH  - Fatty Acids, Unsaturated/administration & dosage/pharmacokinetics
MH  - Female
MH  - Fetal Development
MH  - Fetus/*metabolism
MH  - Glucose/administration & dosage/pharmacokinetics
MH  - Glucose Transport Proteins, Facilitative/genetics/metabolism
MH  - Humans
MH  - Insulin/analysis/metabolism
MH  - Lipid Metabolism
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Maternal-Fetal Exchange
MH  - *Nutritional Status
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/genetics/metabolism
MH  - Trophoblasts/metabolism
MH  - Up-Regulation
EDAT- 2013/02/19 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/19 06:00
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1097/MCO.0b013e32835e3674 [doi]
PST - ppublish
SO  - Curr Opin Clin Nutr Metab Care. 2013 May;16(3):292-7. doi: 
      10.1097/MCO.0b013e32835e3674.