PMID- 23416765
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20151119
IS  - 1532-821X (Electronic)
IS  - 0003-9993 (Linking)
VI  - 94
IP  - 8
DP  - 2013 Aug
TI  - Effectiveness of pulmonary rehabilitation in exercise capacity and quality of 
      life in chronic obstructive pulmonary disease patients with and without global 
      fat-free mass depletion.
PG  - 1607-14
LID - S0003-9993(13)00129-9 [pii]
LID - 10.1016/j.apmr.2013.02.005 [doi]
AB  - OBJECTIVE: To investigate the effectiveness of pulmonary rehabilitation (PR) in 
      exercise capacity and quality of life in patients with chronic obstructive 
      pulmonary disease (COPD) with and without global fat-free mass (FFM) depletion. 
      DESIGN: Retrospective case-control. SETTING: Outpatient clinic, university 
      center. PARTICIPANTS: COPD patients (N=102) that completed PR were initially 
      evaluated. INTERVENTION: PR including whole-body and weight training for 12 
      weeks, 3 times per week. MAIN OUTCOME MEASURES: St. George Respiratory 
      Questionnaire (SGRQ), 6-minute walk distance (6MWD), and FFM evaluation applied 
      before and after PR. RESULTS: Patients were stratified according to their FFM 
      status measured by bioelectric impedance. They were considered depleted if the 
      FFM index was </= 15 kg/m(2) in women and </= 16 kg/m(2) in men. From the initial 
      sample, all depleted patients (n=31) composed the FFM depleted group. It was 
      composed predominantly by women (68%) with a mean age +/- SD of 64.4 +/- 7.3 years 
      and a forced expiratory volume in 1 second of 33.6%=-13.2% predicted. Paired for 
      sex and age, 31 nondepleted patients were selected from the initial sample to 
      compose the nondepleted group. Improvement in the 6MWD was similar in these 2 
      groups after PR. Both groups improved SGRQ scores, although the observed power 
      was small and did not allow adequate comparison between depleted and nondepleted 
      patients. There was no difference between groups in weight change, whereas FFM 
      tended to be greater in depleted patients. This increase had no correlation with 
      the 6MWD or the SGRQ. CONCLUSIONS: Benefits of PR to exercise capacity were 
      similar comparing FFM depleted and nondepleted COPD patients. Although FFM change 
      tended to be greater in depleted patients, this increase had no definite relation 
      with clinical outcomes.
CI  - Copyright (c) 2013 American Congress of Rehabilitation Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Berton, Danilo C
AU  - Berton DC
AD  - Post-Graduate Program in Sciences (Pulmonology), Federal University of Rio Grande 
      do Sul, Porto Alegre, Brazil. dcberton@gmail.com
FAU - Silveira, Leonardo
AU  - Silveira L
FAU - Da Costa, Cassia C
AU  - Da Costa CC
FAU - De Souza, Rafael Machado
AU  - De Souza RM
FAU - Winter, Claudia D
AU  - Winter CD
FAU - Zimermann Teixeira, Paulo Jose
AU  - Zimermann Teixeira PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130214
PL  - United States
TA  - Arch Phys Med Rehabil
JT  - Archives of physical medicine and rehabilitation
JID - 2985158R
SB  - IM
MH  - Body Mass Index
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscular Atrophy/*complications/physiopathology/rehabilitation
MH  - Pulmonary Disease, Chronic 
      Obstructive/*complications/physiopathology/*rehabilitation
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Vital Capacity
OTO - NOTNLM
OT  - 6-minute walk distance
OT  - 6MWD
OT  - BMI
OT  - COPD
OT  - Exercise
OT  - FEV(1)
OT  - FFM
OT  - FVC
OT  - HRQOL
OT  - MANOVA
OT  - MRC
OT  - Medical Research Council
OT  - Muscles
OT  - PR
OT  - Pulmonary disease
OT  - RM
OT  - Rehabilitation
OT  - SGRQ
OT  - St. George Respiratory Questionnaire
OT  - body mass index
OT  - chronic obstructive
OT  - chronic obstructive pulmonary disease
OT  - fat-free mass
OT  - forced expiratory volume in 1 second
OT  - forced vital capacity
OT  - health-related quality of life
OT  - multiple analysis of variance
OT  - pulmonary rehabilitation
OT  - repetition maximum
EDAT- 2013/02/19 06:00
MHDA- 2013/11/01 06:00
CRDT- 2013/02/19 06:00
PHST- 2012/08/03 00:00 [received]
PHST- 2013/01/24 00:00 [revised]
PHST- 2013/02/04 00:00 [accepted]
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - S0003-9993(13)00129-9 [pii]
AID - 10.1016/j.apmr.2013.02.005 [doi]
PST - ppublish
SO  - Arch Phys Med Rehabil. 2013 Aug;94(8):1607-14. doi: 10.1016/j.apmr.2013.02.005. 
      Epub 2013 Feb 14.