PMID- 23417225
OWN - NLM
STAT- MEDLINE
DCOM- 20131105
LR  - 20161125
IS  - 1864-6433 (Electronic)
IS  - 0914-7187 (Linking)
VI  - 27
IP  - 4
DP  - 2013 May
TI  - Assessment of FDG retention differences between the FDG-avid benign pulmonary 
      lesion and primary lung cancer using dual-time-point FDG-PET imaging.
PG  - 392-9
LID - 10.1007/s12149-013-0698-4 [doi]
AB  - PURPOSE: The aim of this study was to clarify FDG retention differences between 
      FDG-avid benign pulmonary lesions (BPLs) and primary lung cancers (PLCs), and 
      between tuberculous and non-tuberculous BPLs using dual-time-point FDG-PET 
      imaging. METHODS: Thirty-four BPLs and 47 PLCs with a maximal standardized uptake 
      value (SUVmax) >2.5 and a maximal axial diameter >10 mm were enrolled. We 
      compared the retention index (RI) among different types of lesions, and evaluated 
      the relationship between RI and SUVmax at 1 h (SUV1). Glucose transporter-1 
      (Glut-1) and hexokinase (HK)-2 expression was assessed in eight non-tuberculous 
      BPLs. RESULTS: BPLs and PLCs showed similar high RIs (mean +/- SD 33.6 +/- 22.6 and 
      32.5 +/- 23.7, respectively; p = 0.95). In BPLs, both tuberculous and 
      non-tuberculous lesions showed high RIs (39.1 +/- 25.8 and 30.3 +/- 20.3, 
      respectively; p = 0.43). However, BPLs and PLCs exhibited a different 
      relationship between RI and SUV1. BPLs tended to show lower RIs with higher 
      SUV1s, and a mild negative correlation, whereas PLCs showed persistent high RIs 
      and no significant correlation. Glut-1 and HK-2 expression was found in 75 and 
      12.5 % of non-tuberculous BPLs, respectively. CONCLUSIONS: FDG-avid BPLs could 
      show high RIs regardless of their being tuberculous and non-tuberculous lesions, 
      and no significant difference with PLC RIs was found. FDG-avid BPLs and PLCs 
      showed different relationships between RI and SUV1, and it seemed to be related 
      with different mechanisms of high FDG retention. However, the mechanisms of high 
      FDG retention in FDG-avid BPLs remain unclear, and this matter requires further 
      investigation.
FAU - Kaneko, Koichiro
AU  - Kaneko K
AD  - PET Imaging Center, Koga Hospital 21, 3-3-8 Miyanojin, Kurume, 839-0801, Japan. 
      kkaneko-kyu@umin.ac.jp
FAU - Sadashima, Eiji
AU  - Sadashima E
FAU - Irie, Koji
AU  - Irie K
FAU - Hayashi, Akihiro
AU  - Hayashi A
FAU - Masunari, Satoru
AU  - Masunari S
FAU - Yoshida, Tsuyoshi
AU  - Yoshida T
FAU - Omagari, Junichi
AU  - Omagari J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130217
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
EIN - Ann Nucl Med. 2013 Oct;27(8):793. Sadashima, Shinji [corrected to Sadashima, 
      Eiji]
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diagnosis, Differential
MH  - Female
MH  - Fluorodeoxyglucose F18/*pharmacokinetics
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/*metabolism
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Middle Aged
MH  - Positron-Emission Tomography/*methods
MH  - Radiopharmaceuticals/pharmacokinetics
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tissue Distribution
MH  - Tuberculosis, Pulmonary/*diagnostic imaging/*metabolism
EDAT- 2013/02/19 06:00
MHDA- 2013/11/06 06:00
CRDT- 2013/02/19 06:00
PHST- 2012/12/02 00:00 [received]
PHST- 2013/02/03 00:00 [accepted]
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2013/11/06 06:00 [medline]
AID - 10.1007/s12149-013-0698-4 [doi]
PST - ppublish
SO  - Ann Nucl Med. 2013 May;27(4):392-9. doi: 10.1007/s12149-013-0698-4. Epub 2013 Feb 
      17.