PMID- 23417757
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20221207
IS  - 1432-0584 (Electronic)
IS  - 0939-5555 (Linking)
VI  - 92
IP  - 6
DP  - 2013 Jun
TI  - Chromosomal abnormalities by conventional cytogenetics and interphase 
      fluorescence in situ hybridization in chronic lymphocytic leukemia in Taiwan, an 
      area with low incidence--clinical implication and comparison between the West and 
      the East.
PG  - 799-806
LID - 10.1007/s00277-013-1700-x [doi]
AB  - Chronic lymphocytic leukemia (CLL) is much less prevalent in Taiwan than in the 
      West, but we have recently addressed the distinctly increasing incidence of CLL 
      in Taiwan. We sought to find out whether there is any difference in cytogenetic 
      abnormalities (CA) of CLL between the West and the East. We analyze the CA, by 
      conventional cytogenetics (CG) and fluorescence in situ hybridization (FISH), and 
      their clinical significance in 83 Taiwanese CLL patients and compared the data to 
      those of Western countries. Thirty-five patients (42.2 %) possessed CG-CA and 58 
      (69.9 %) FISH-CA. By either CG or FISH, deletion of 17p or 11q was associated 
      with poorer overall survival (OS) (P<0.001 and P=0.008, respectively), whereas 
      isolated 13q deletion was associated with better OS (P=0.050). Trisomy 3 by CG 
      was found in five patients; all of them were in Binet A stage but had strikingly 
      poor OS (P<0.001). This prognostic impact was independent from the other CA and 
      Binet stages. We conclude that, though the disease incidence is much different, 
      the CA of CLL in Taiwan are similar to those in the West. The combined CG and 
      FISH analysis is able to predict the patients' prognosis. The clinical 
      significance of trisomy 3 warrants further validation.
FAU - Wu, Shang-Ju
AU  - Wu SJ
AD  - Division of Hematology, Department of Internal Medicine, National Taiwan 
      University Hospital, Taipei, 100, Taiwan.
FAU - Lin, Chien-Ting
AU  - Lin CT
FAU - Huang, Sheng-Yi
AU  - Huang SY
FAU - Lee, Fen-Yu
AU  - Lee FY
FAU - Liu, Ming-Chi
AU  - Liu MC
FAU - Hou, Hsin-An
AU  - Hou HA
FAU - Chen, Chien-Yuan
AU  - Chen CY
FAU - Ko, Bor-Sheng
AU  - Ko BS
FAU - Chou, Wen-Chien
AU  - Chou WC
FAU - Yao, Ming
AU  - Yao M
FAU - Tang, Jih-Luh
AU  - Tang JL
FAU - Tsay, Woei
AU  - Tsay W
FAU - Tien, Hwei-Fang
AU  - Tien HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130217
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
SB  - IM
MH  - Aged
MH  - Aneuploidy
MH  - Asian People/statistics & numerical data
MH  - Bone Marrow Examination/methods
MH  - *Chromosome Aberrations
MH  - *Chromosome Banding
MH  - Chromosomes, Human, Pair 3/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Incidence
MH  - Interphase
MH  - Kaplan-Meier Estimate
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Taiwan/epidemiology
MH  - Trisomy
MH  - United States/epidemiology
MH  - White People/statistics & numerical data
EDAT- 2013/02/19 06:00
MHDA- 2013/07/10 06:00
CRDT- 2013/02/19 06:00
PHST- 2011/11/16 00:00 [received]
PHST- 2012/10/12 00:00 [accepted]
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 10.1007/s00277-013-1700-x [doi]
PST - ppublish
SO  - Ann Hematol. 2013 Jun;92(6):799-806. doi: 10.1007/s00277-013-1700-x. Epub 2013 
      Feb 17.