PMID- 23418772
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20211021
IS  - 1742-481X (Electronic)
IS  - 1742-4801 (Print)
IS  - 1742-4801 (Linking)
VI  - 12
IP  - 1
DP  - 2015 Feb
TI  - Hyperhomocysteinaemia and chronic venous ulcers.
PG  - 22-6
LID - 10.1111/iwj.12042 [doi]
AB  - Chronic venous ulceration (CVU) is the major cause of chronic wounds of lower 
      extremities, and is a part of the complex of chronic venous disease. Previous 
      studies have hypothesised that several thrombophilic factors, such as 
      hyperhomocysteinaemia (HHcy), may be associated with chronic venous ulcers. In 
      this study, we evaluated the prevalence of HHcy in patients with venous leg 
      ulcers and the effect of folic acid therapy on wound healing. Eighty-seven 
      patients with venous leg ulcers were enrolled in this study to calculate the 
      prevalence of HHcy in this population. All patients underwent basic treatment for 
      venous ulcer (compression therapy +/- surgical procedures). Patients with HHcy 
      (group A) received basic treatment and administered folic acid (1.2 mg/day for 12 
      months) and patients without HHcy (group B) received only basic treatment. 
      Healing was assessed by means of computerised planimetry analysis. The prevalence 
      of HHcy among patients with chronic venous ulcer enrolled in this study was 
      62.06%. Healing rate was significantly higher (P < 0.05) in group A patients 
      (78.75%) compared with group B patients (63.33%). This study suggests a close 
      association, statistically significant, between HHcy and CVU. 
      Homocysteine-lowering therapy with folic acid seems to expedite wound healing. 
      Despite these aspects, the exact molecular mechanisms between homocysteine and 
      CVU have not been clearly defined and further studies are needed.
CI  - (c) 2013 The Authors. International Wound Journal (c) 2013 Medicalhelplines.com Inc 
      and John Wiley & Sons Ltd.
FAU - de Franciscis, Stefano
AU  - de Franciscis S
AD  - Department of Medical and Surgical Science, School of Medicine, University Magna 
      Graecia of Catanzaro, Catanzaro, Italy; Interuniversity Center of 
      Phlebolymphology, International Research and Educational Program in Clinical and 
      Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, 
      Italy.
FAU - De Sarro, Giovambattista
AU  - De Sarro G
FAU - Longo, Paola
AU  - Longo P
FAU - Buffone, Gianluca
AU  - Buffone G
FAU - Molinari, Vincenzo
AU  - Molinari V
FAU - Stillitano, Domenico M
AU  - Stillitano DM
FAU - Gallelli, Luca
AU  - Gallelli L
FAU - Serra, Raffaele
AU  - Serra R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20130219
PL  - England
TA  - Int Wound J
JT  - International wound journal
JID - 101230907
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
RN  - Homocysteinemia
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Female
MH  - Folic Acid/*therapeutic use
MH  - Humans
MH  - Hyperhomocysteinemia/diagnosis/*drug therapy/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Varicose Ulcer/blood/*complications/*drug therapy
MH  - Vitamin B Complex/*therapeutic use
MH  - Wound Healing
PMC - PMC7950680
OTO - NOTNLM
OT  - Chronic venous disease
OT  - Chronic venous ulceration
OT  - Hyperhomocysteinaemia
OT  - Thrombophilia
OT  - Venous leg ulcer
EDAT- 2013/02/20 06:00
MHDA- 2015/10/27 06:00
PMCR- 2013/02/19
CRDT- 2013/02/20 06:00
PHST- 2013/01/04 00:00 [received]
PHST- 2013/01/12 00:00 [accepted]
PHST- 2013/02/20 06:00 [entrez]
PHST- 2013/02/20 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
PHST- 2013/02/19 00:00 [pmc-release]
AID - IWJ12042 [pii]
AID - 10.1111/iwj.12042 [doi]
PST - ppublish
SO  - Int Wound J. 2015 Feb;12(1):22-6. doi: 10.1111/iwj.12042. Epub 2013 Feb 19.