PMID- 23420524
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20161125
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 138
IP  - 7
DP  - 2013 Apr 7
TI  - Development and applications of paper-based electrospray ionization-mass 
      spectrometry for monitoring of sequentially generated droplets.
PG  - 2163-70
LID - 10.1039/c3an36404f [doi]
AB  - In this work, sub-microlitre droplets were generated by gravity and electrostatic 
      attraction using a capillary tube. The parameters affecting the sizes and 
      frequency of the droplets were investigated. The volume of droplets could be 
      controlled in the range from 0.7 muL to 2.4 muL and the time interval from 15 s to 
      60 s with appropriate parameters. Combining the droplets with on-line mass 
      spectrometry (MS) via paper-based electrospray ionization (ESI), a steady flow of 
      solvent was delivered by the capillary tube to the base-side of the paper, which 
      maintained the consistent state of the electrospray. With this approach, each 
      droplet produced a peak in the ion chromatogram. Relative standard deviations 
      (RSDs) not higher than 9% for both the intensities and the time intervals were 
      achieved when using rhodamine 6G and l-phenylalanine as model analytes. The 
      present method was utilized for the monitoring of the amine-aldehyde condensation 
      reaction of butylamine and benzaldehyde. Direct analysis and distribution of 
      molecules in fruits were also performed, which demonstrated the potential 
      application of this approach.
FAU - Liu, Wu
AU  - Liu W
AD  - Beijing Key Laboratory of Microanalytical Method and Instrumentation, Department 
      of Chemistry, Tsinghua University, Beijing 100084, PR China.
FAU - Mao, Sifeng
AU  - Mao S
FAU - Wu, Jing
AU  - Wu J
FAU - Lin, Jin-Ming
AU  - Lin JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130219
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Benzaldehydes)
RN  - 0 (Butylamines)
RN  - 0 (Rhodamines)
RN  - 0 (Solvents)
RN  - 037VRW83CF (rhodamine 6G)
RN  - 47E5O17Y3R (Phenylalanine)
RN  - TA269SD04T (benzaldehyde)
SB  - IM
MH  - Benzaldehydes/chemistry
MH  - Beverages/analysis
MH  - Butylamines/chemistry
MH  - Fruit/chemistry
MH  - Gravitation
MH  - Microchemistry/methods
MH  - Phenylalanine/isolation & purification
MH  - Rhodamines/isolation & purification
MH  - Solvents
MH  - Spectrometry, Mass, Electrospray Ionization/*methods
MH  - Static Electricity
EDAT- 2013/02/20 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/20 06:00
PHST- 2013/02/20 06:00 [entrez]
PHST- 2013/02/20 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1039/c3an36404f [doi]
PST - ppublish
SO  - Analyst. 2013 Apr 7;138(7):2163-70. doi: 10.1039/c3an36404f. Epub 2013 Feb 19.