PMID- 23420725
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2013
DP  - 2013 Feb 18
TI  - Clinical challenges of an oligosecretory plasma cell dyscrasia.
LID - 10.1136/bcr-2012-008169 [doi]
LID - bcr2012008169
AB  - Light chain deposition disease (LCDD) and immunoglobulin light chain (AL) 
      amyloidosis are uncommon, and heterogeneous clonal plasma cell (PC) proliferative 
      disorders defined by the different biochemical characteristics of the underlying 
      anomalous immunoglobulin. The deposits are usually multisystemic and the two 
      diseases can coexist. The diagnosis is sometimes made difficult by the absence of 
      a detectable paraprotein by routine immunofixation techniques, and the use of 
      serum-free light chain (FLC) immunoassay brought new value in terms of their 
      diagnosis, prognosis and assessment of treatment response. Association of LCDD 
      and AL amyloidosis with multiple myeloma (MM) at the time of diagnosis is common, 
      but further progression to this condition is considered rare. We present a case 
      of a patient diagnosed with systemic LCDD and AL amyloidosis of atypical 
      biochemical characteristics, with no paraprotein detected in 
      immunoelectrophoresis and immunofixation techniques, who progressed to MM in the 
      later course of her disease.
FAU - Rodrigues, Luis
AU  - Rodrigues L
AD  - Department of Nephrology, Centro Hospitalar e Universitario de Coimbra, Coimbra, 
      Portugal, Portugal. luis.arodrigues@hotmail.com
FAU - Neves, Marta
AU  - Neves M
FAU - Sa, Helena
AU  - Sa H
FAU - Campos, Mario
AU  - Campos M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130218
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Immunoglobulin kappa-Chains)
RN  - 0 (Serum Amyloid P-Component)
SB  - IM
MH  - Adult
MH  - Amyloidosis/complications/diagnosis
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Hypertension/etiology
MH  - Immunoassay/methods
MH  - Immunoglobulin kappa-Chains/metabolism
MH  - Liver/pathology
MH  - Paraproteinemias/complications/*diagnosis/pathology
MH  - Peritoneal Dialysis
MH  - Renal Insufficiency, Chronic/etiology/therapy
MH  - Serum Amyloid P-Component/metabolism
PMC - PMC3604379
EDAT- 2013/02/20 06:00
MHDA- 2013/09/17 06:00
PMCR- 2015/02/18
CRDT- 2013/02/20 06:00
PHST- 2013/02/20 06:00 [entrez]
PHST- 2013/02/20 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
PHST- 2015/02/18 00:00 [pmc-release]
AID - bcr-2012-008169 [pii]
AID - 10.1136/bcr-2012-008169 [doi]
PST - epublish
SO  - BMJ Case Rep. 2013 Feb 18;2013:bcr2012008169. doi: 10.1136/bcr-2012-008169.