PMID- 23420820
OWN - NLM
STAT- MEDLINE
DCOM- 20140120
LR  - 20211021
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Print)
IS  - 1933-7191 (Linking)
VI  - 20
IP  - 9
DP  - 2013 Sep
TI  - Effect of pregnancy and nitric oxide on the myogenic vasodilation of posterior 
      cerebral arteries and the lower limit of cerebral blood flow autoregulation.
PG  - 1046-54
LID - 10.1177/1933719112473661 [doi]
AB  - Hemorrhage during parturition can lower blood pressure beyond the lower limit of 
      cerebral blood flow (CBF) autoregulation that can cause ischemic brain injury. 
      However, the impact of pregnancy on the lower limit of CBF autoregulation is 
      unknown. We measured myogenic vasodilation, a major contributor of CBF 
      autoregulation, in isolated posterior cerebral arteries (PCAs) from nonpregnant 
      and late-pregnant rats (n = 10/group) while the effect of pregnancy on the lower 
      limit of CBF autoregulation was studied in the posterior cerebral cortex during 
      controlled hemorrhage (n = 8). Pregnancy enhanced myogenic vasodilation in PCA 
      and shifted the lower limit of CBF autoregulation to lower pressures. Inhibition 
      of nitric oxide synthase (NOS) prevented the enhanced myogenic vasodilation 
      during pregnancy but did not affect the lower limit of CBF autoregulation. The 
      shift in the autoregulatory curve to lower pressures during pregnancy is likely 
      protective of ischemic injury during hemorrhage and appears to be independent of 
      NOS.
FAU - Chapman, Abbie C
AU  - Chapman AC
AD  - Neuroscience Graduate Program, University of Vermont College of Medicine, 
      Burlington, VT 05405, USA.
FAU - Cipolla, Marilyn J
AU  - Cipolla MJ
FAU - Chan, Siu-Lung
AU  - Chan SL
LA  - eng
GR  - P01 HL095488/HL/NHLBI NIH HHS/United States
GR  - R01 NS045940/NS/NINDS NIH HHS/United States
GR  - R01 NS045940-06S1/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130218
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Enzyme Inhibitors)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Animals
MH  - Arterial Pressure
MH  - Brain Ischemia/metabolism/physiopathology/prevention & control
MH  - *Cerebrovascular Circulation/drug effects
MH  - Disease Models, Animal
MH  - Enzyme Inhibitors/pharmacology
MH  - Female
MH  - Hemorrhage/metabolism/physiopathology
MH  - Homeostasis
MH  - Hypotension/metabolism/physiopathology
MH  - Muscle, Smooth, Vascular/drug effects/*metabolism/physiopathology
MH  - Nitric Oxide/*metabolism
MH  - Nitric Oxide Synthase/antagonists & inhibitors/metabolism
MH  - Posterior Cerebral Artery/metabolism/physiopathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Vasodilation/drug effects
PMC - PMC3745710
OTO - NOTNLM
OT  - CBF autoregulation
OT  - hypotension
OT  - myogenic vasodilation
OT  - nitric oxide
OT  - pregnancy
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2013/02/20 06:00
MHDA- 2014/01/21 06:00
PMCR- 2014/09/01
CRDT- 2013/02/20 06:00
PHST- 2013/02/20 06:00 [entrez]
PHST- 2013/02/20 06:00 [pubmed]
PHST- 2014/01/21 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 1933719112473661 [pii]
AID - 10.1177_1933719112473661 [pii]
AID - 10.1177/1933719112473661 [doi]
PST - ppublish
SO  - Reprod Sci. 2013 Sep;20(9):1046-54. doi: 10.1177/1933719112473661. Epub 2013 Feb 
      18.