PMID- 23422203
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20130220
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 126
IP  - 4
DP  - 2013 Feb
TI  - Cord blood transplantation for the treatment of acute leukemia.
PG  - 761-7
AB  - OBJECTIVE: This review discussed the available data on treatment outcomes of cord 
      blood transplantation (CBT) for acute leukemia. DATA SOURCES: The data cited in 
      this review were obtained from articles listed in Medline and Pubmed. STUDY 
      SELECTION: We reviewed the articles of clinical results from various registries 
      and institutions, as well as our experiences with CBT in children, adolescents 
      and adults. RESULTS: This research has clearly shown that cord blood (CB) has 
      several unique characteristics resulting in distinct advantage and disadvantages 
      when compared to transplantation with unrelated donor bone marrow or peripheral 
      blood stem cells. The field of CBT has advanced from investigating its safety and 
      feasibility to addressing more specific issues such as accelerating engraftment, 
      extending access, and examining outcomes in specific subgroups of patients. Many 
      approaches have been investigated in the attempt to improve engraftment and 
      survival. Variable factors have been identified, such as factors related to donor 
      choice (human leukocyte antigen (HLA) compatibility, cell dose, and others) and 
      transplantation (conditioning and graft-versus-host disease prophylaxis regimen). 
      Data support that CB should be considered a reasonable option in those that do 
      not have HLA matched sibling donor and for those in whom the time to transplant 
      is critical. CONCLUSIONS: CB is a reasonable alternative to unrelated donor bone 
      marrow or peripheral blood progenitor cells for transplantation. Recently 
      developed strategies aimed at improving hematopoietic recovery and reducing early 
      transplantation-related mortality could further improve treatment outcomes of CBT 
      for patients with acute leukemia.
FAU - Park, Meerim
AU  - Park M
AD  - Department of Pediatrics, College of Medicine, Chungbuk National University, 
      Cheongju, Korea.
FAU - Lee, Young-ho
AU  - Lee YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Acute Disease
MH  - Fetal Blood/*transplantation
MH  - Humans
MH  - Leukemia/*therapy
EDAT- 2013/02/21 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/21 06:00
PHST- 2013/02/21 06:00 [entrez]
PHST- 2013/02/21 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2013 Feb;126(4):761-7.