PMID- 23422338
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20220316
IS  - 1875-8622 (Electronic)
IS  - 1386-0291 (Linking)
VI  - 56
IP  - 2
DP  - 2014
TI  - Homocysteine levels in patients with primary and secondary Raynaud's phenomenon. 
      Its association with microangiopathy severity.
PG  - 153-9
LID - 10.3233/CH-131681 [doi]
AB  - The association between hyperhomocysteinemia (HHcy) and Raynaud's phenomenon (RP) 
      remains a matter of debate. In 18 primary RP, 23 secondary RP and 41 controls, we 
      investigated homocysteine (Hcy) levels along with biochemical and inflammatory 
      parameters. The Hcy levels in both primary and secondary RP were elevated when 
      compared with controls (p < 0.05 and p < 0.01, respectively). As age was higher 
      in secondary RP as compared with controls (p < 0.01), both primary and secondary 
      RP were age-matched with a corresponding control group, and with Hcy maintaining 
      its statistical significance (p < 0.05). No differences in creatinine, B12 
      vitamin or folic acid were observed between groups (p > 0.05), or in the 
      prevalence of cardiovascular risk factors (p > 0.05). When patients were 
      classified according to presence or absence of digital ulcers, as a sign of 
      microangiopathy severity, the former showed higher Hcy levels than the latter (p 
      = 0.035). Our results indicate that both primary and secondary RP patients show a 
      mild increase in Hcy levels, which is not related to age, vitamin deficiencies or 
      impaired renal function, but is related to microangiopathy severity. Therefore 
      the association of HHcy and RP suggest that Hcy may contribute to endothelial 
      dysregulation, which characterizes this disease. Specific studies should be 
      designed to elucidate the pathogenesis of HHcy in these patients.
FAU - Vaya, Amparo
AU  - Vaya A
AD  - Hemorheology and Hemostasis Unit, Service of Clinical Pathology, La Fe University 
      Hospital, Valencia, Spain.
FAU - Sanchez, Fernando
AU  - Sanchez F
AD  - Hemorheology and Hemostasis Unit, Service of Clinical Pathology, La Fe University 
      Hospital, Valencia, Spain.
FAU - Todoli, Jose
AU  - Todoli J
AD  - Internal Medicine Service, La Fe University Hospital, Valencia, Spain.
FAU - Calvo, Javier
AU  - Calvo J
AD  - Rheumatology Service, General Hospital, Valencia, Spain.
FAU - Alis, Rafael
AU  - Alis R
AD  - School of Medicine, Catholic University of Valencia, Spain.
FAU - Collado, Susana
AU  - Collado S
AD  - Hemorheology and Hemostasis Unit, Service of Clinical Pathology, La Fe University 
      Hospital, Valencia, Spain.
FAU - Ricart, Jose M
AU  - Ricart JM
AD  - Dermatology Service, La Fe University Hospital, Valencia, Spain.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Hemorheol Microcirc
JT  - Clinical hemorheology and microcirculation
JID - 9709206
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Capillaries/pathology
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Microcirculation
MH  - Middle Aged
MH  - Raynaud Disease/*blood/complications/pathology
MH  - Vitamin B 12/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Raynaud's phenomenon
OT  - homocysteine
OT  - microangiopathy
EDAT- 2013/02/21 06:00
MHDA- 2014/11/13 06:00
CRDT- 2013/02/21 06:00
PHST- 2013/02/21 06:00 [entrez]
PHST- 2013/02/21 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - 935W808243336Q46 [pii]
AID - 10.3233/CH-131681 [doi]
PST - ppublish
SO  - Clin Hemorheol Microcirc. 2014;56(2):153-9. doi: 10.3233/CH-131681.