PMID- 23423358
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130221
LR  - 20211021
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 5
DP  - 2013
TI  - Cerebellar theta burst stimulation modulates short latency afferent inhibition in 
      Alzheimer's disease patients.
PG  - 2
LID - 10.3389/fnagi.2013.00002 [doi]
LID - 2
AB  - The dysfunction of cholinergic neurons is a typical hallmark in Alzheimer's 
      disease (AD). Previous findings demonstrated that high density of cholinergic 
      receptors is found in the thalamus and the cerebellum compared with the cerebral 
      cortex and the hippocampus. We aimed at investigating whether activation of the 
      cerebello-thalamo-cortical pathway by means of cerebellar theta burst stimulation 
      (TBS) could modulate central cholinergic functions evaluated in vivo by using the 
      neurophysiological determination of Short-Latency Afferent Inhibition (SLAI). We 
      tested the SLAI circuit before and after administration of cerebellar continuous 
      TBS (cTBS) in 12 AD patients and in 12 healthy age-matched control subjects (HS). 
      We also investigated potential changes of intracortical circuits of the 
      contralateral primary motor cortex (M1) by assessing short intracortical 
      inhibition (SICI) and intracortical facilitation (ICF). SLAI was decreased in AD 
      patients compared to HS. Cerebellar cTBS partially restored SLAI in AD patients 
      at later inter-stimulus intervals (ISIs), but did not modify SLAI in HS. SICI and 
      ICF did not differ in the two groups and were not modulated by cerebellar cTBS. 
      These results demonstrate that cerebellar magnetic stimulation is likely to 
      affect mechanisms of cortical cholinergic activity, suggesting that the 
      cerebellum may have a direct influence on the cholinergic dysfunction in AD.
FAU - Di Lorenzo, Francesco
AU  - Di Lorenzo F
AD  - Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS Rome, Italy.
FAU - Martorana, Alessandro
AU  - Martorana A
FAU - Ponzo, Viviana
AU  - Ponzo V
FAU - Bonni, Sonia
AU  - Bonni S
FAU - D'Angelo, Egidio
AU  - D'Angelo E
FAU - Caltagirone, Carlo
AU  - Caltagirone C
FAU - Koch, Giacomo
AU  - Koch G
LA  - eng
PT  - Journal Article
DEP - 20130219
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC3575596
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cerebellum
OT  - cholinergic
OT  - cortical plasticity
OT  - transcranial magnetic stimulation
EDAT- 2013/02/21 06:00
MHDA- 2013/02/21 06:01
PMCR- 2013/01/01
CRDT- 2013/02/21 06:00
PHST- 2012/12/13 00:00 [received]
PHST- 2013/01/25 00:00 [accepted]
PHST- 2013/02/21 06:00 [entrez]
PHST- 2013/02/21 06:00 [pubmed]
PHST- 2013/02/21 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2013.00002 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2013 Feb 19;5:2. doi: 10.3389/fnagi.2013.00002. eCollection 
      2013.