PMID- 23423470
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130221
LR  - 20220410
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 3
DP  - 2012
TI  - Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis 
      reveals that association between these conditions diminished over time and is 
      modified by clinical characteristics.
PG  - 182
LID - 10.3389/fendo.2012.00182 [doi]
LID - 182
AB  - INTRODUCTION: Risk of testicular germ cell tumors (TGCT) is consistently 
      associated with a history of cryptorchidism (CO) in epidemiologic studies. 
      Factors modifying the association may provide insights regarding etiology of TGCT 
      and suggest a basis for individualized care of CO. To identify modifiers of the 
      CO-TGCT association, we conducted a comprehensive, quantitative evaluation of 
      epidemiologic data. MATERIALS AND METHODS: Human studies cited in PubMed or ISI 
      Web of Science indices through December 2011 and selected unpublished 
      epidemiologic data were reviewed to identify 35 articles and one unpublished 
      dataset with high-quality data on the CO-TGCT association. Association data were 
      extracted as point and 95% confidence interval estimates of odds ratio (OR) or 
      standardized incidence ratio (SIR), or as tabulated data. Values were recorded 
      for each study population, and for subgroups defined by features of study design, 
      CO and TGCT. Extracted data were used to estimate summary risk ratios (sRR) and 
      evaluate heterogeneity of the CO-TGCT association between subgroups. RESULTS: The 
      overall meta-analysis showed that history of CO is associated with four-fold 
      increased TGCT risk [RR = 4.1(95% CI = 3.6-4.7)]. Subgroup analyses identified 
      five determinants of stronger association: bilateral CO, unilateral CO 
      ipsilateral to TGCT, delayed CO treatment, TGCT diagnosed before 1970, and 
      seminoma histology. CONCLUSIONS: Modifying factors may provide insight into TGCT 
      etiology and suggest improved approaches to managing CO. Based on available data, 
      CO patients and their parents or caregivers should be made aware of elevated TGCT 
      risk following orchidopexy, regardless of age at repair, unilateral vs. bilateral 
      non-descent, or position of undescended testes.
FAU - Banks, Kimberly
AU  - Banks K
AD  - Keck School of Medicine, University of Southern California Los Angeles, CA, USA ; 
      City of Hope National Medical Center Duarte, CA, USA ; St. Joseph Hospital 
      Orange, CA, USA.
FAU - Tuazon, Ellenie
AU  - Tuazon E
FAU - Berhane, Kiros
AU  - Berhane K
FAU - Koh, Chester J
AU  - Koh CJ
FAU - De Filippo, Roger E
AU  - De Filippo RE
FAU - Chang, Andy
AU  - Chang A
FAU - Kim, Steve S
AU  - Kim SS
FAU - Daneshmand, Siamak
AU  - Daneshmand S
FAU - Davis-Dao, Carol
AU  - Davis-Dao C
FAU - Lewinger, Juan P
AU  - Lewinger JP
FAU - Bernstein, Leslie
AU  - Bernstein L
FAU - Cortessis, Victoria K
AU  - Cortessis VK
LA  - eng
GR  - K05 CA136967/CA/NCI NIH HHS/United States
GR  - R01 CA102042/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20130218
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC3574983
OTO - NOTNLM
OT  - cryptorchidism
OT  - meta-analysis
OT  - non-seminoma
OT  - seminoma
OT  - testicular neoplasms
EDAT- 2013/02/21 06:00
MHDA- 2013/02/21 06:01
PMCR- 2012/01/01
CRDT- 2013/02/21 06:00
PHST- 2012/09/30 00:00 [received]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/02/21 06:00 [entrez]
PHST- 2013/02/21 06:00 [pubmed]
PHST- 2013/02/21 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2012.00182 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2013 Feb 18;3:182. doi: 10.3389/fendo.2012.00182. 
      eCollection 2012.