PMID- 23424997
OWN - NLM
STAT- MEDLINE
DCOM- 20130910
LR  - 20220310
IS  - 1502-7732 (Electronic)
IS  - 0300-9742 (Linking)
VI  - 42
IP  - 4
DP  - 2013
TI  - Relationship between iron metabolism, oxidative stress, and insulin resistance in 
      patients with systemic lupus erythematosus.
PG  - 303-10
LID - 10.3109/03009742.2012.754942 [doi]
AB  - OBJECTIVE: The aim of the present study was to assess oxidative stress and iron 
      metabolism in systemic lupus erythematosus (SLE) patients with and without 
      insulin resistance (IR). METHOD: This study included 236 subjects (125 controls 
      and 111 SLE patients). Patients with SLE were divided in two groups: with (n = 
      72) or without (n = 39) IR. RESULTS: SLE patients with IR showed higher advanced 
      oxidation protein product (AOPP) levels (p = 0.030) and gamma-glutamyltransferase 
      (GGT) levels (p = 0.001) and lower sulfhydryl groups of proteins (p = 0.0002) and 
      total radical-trapping antioxidant parameter (TRAP) corrected by uric acid (UA) 
      levels (p = 0.04) when compared to SLE patients without IR. However, SLE patients 
      with IR presented lower serum 8-isoprostane (p = 0.05) and carbonyl protein 
      levels (p = 0.04) when compared to SLE patients without IR. Serum ferritin levels 
      were significantly higher in SLE patients (p = 0.0006) than in controls, and SLE 
      patients with IR presented higher serum ferritin levels (p = 0.01) than SLE 
      patients without IR. Patients with SLE showed that IR was inversely correlated to 
      TRAP/UA (r = -0.2724, p = 0.0008) and serum ferritin was positively correlated to 
      AOPP (r = 0.2870, p = 0.004). CONCLUSIONS: This study found that oxidative stress 
      was higher in the group of SLE patients with IR, and increased ferritin, whether 
      caused by the inflammatory process per se or hyperinsulinaemia, can favour the 
      redox process. In addition, the preset data reinforce the need to measure 
      oxidative stress with several methodologies with different assumptions.
FAU - Lozovoy, M A B
AU  - Lozovoy MA
AD  - Department of Clinical Analysis, University North of Parana (UNOPAR), Parana, 
      Brazil.
FAU - Simao, A N C
AU  - Simao AN
FAU - Oliveira, S R
AU  - Oliveira SR
FAU - Iryioda, T M V
AU  - Iryioda TM
FAU - Panis, C
AU  - Panis C
FAU - Cecchini, R
AU  - Cecchini R
FAU - Dichi, I
AU  - Dichi I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130220
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
RN  - 0 (Biomarkers)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - 9007-73-2 (Ferritins)
RN  - B7IN85G1HY (Dinoprost)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Anthropometry
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Dinoprost/analogs & derivatives/metabolism
MH  - Disease Progression
MH  - Female
MH  - Ferritins/*metabolism
MH  - Follow-Up Studies
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Lupus Erythematosus, Systemic/*metabolism/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Sex Factors
MH  - Statistics, Nonparametric
MH  - gamma-Glutamyltransferase/metabolism
EDAT- 2013/02/22 06:00
MHDA- 2013/09/11 06:00
CRDT- 2013/02/22 06:00
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2013/09/11 06:00 [medline]
AID - 10.3109/03009742.2012.754942 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 2013;42(4):303-10. doi: 10.3109/03009742.2012.754942. Epub 
      2013 Feb 20.