PMID- 23425059
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20130522
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 28
IP  - 6
DP  - 2013 Jun
TI  - Transition zone defect associated with the response to proton pump inhibitor 
      treatment in patients with globus sensation.
PG  - 954-62
LID - 10.1111/jgh.12136 [doi]
AB  - BACKGROUND AND AIM: Few data describing short-term proton pump inhibitor (PPI) 
      treatment in patients with globus sensation exist. The aim of this study was to 
      evaluate the use of high-resolution manometry (HRM) for predicting the response 
      to PPI treatment in patients with globus sensation. METHOD: A total of 41 
      patients with globus sensation were treated with PPIs for 4 weeks and were 
      classified as positive and negative responders. HRM topographical plots were 
      analyzed for relevant manometric parameters. In addition, clinical and HRM data 
      of 20 patients with typical gastroesophageal reflux disease (GERD) not presenting 
      globus symptom were analyzed. RESULTS: Of the 41 patients, 19 (46%) were 
      clinically diagnosed with GERD. The proportion of patients with favorable 
      symptomatic improvement was higher in patients with GERD than in those without 
      reflux (P=0.046). Positive and negative responders to PPI treatment did not 
      differ in upper esophageal sphincter and proximal esophageal contraction. In 
      globus patients with GERD, the temporal and spatial dimension of the transitional 
      zone were greater among negative responders than among PPI-positive responders 
      (P=0.010 and P=0.011). Regarding GERD patients without globus, there was no 
      significant difference in transition zone defect according to PPI responsiveness. 
      By receiver operating characteristic curve analysis, 2.1 cm and 1.1 s were found 
      to be the spatial and temporal transitional zone dimensions that best 
      differentiated positive and negative responders. CONCLUSION: In patients with 
      GERD-related globus, there were larger transition zone defect in the negative 
      responders compared with the PPI-positive responders.
CI  - (c) 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing 
      Asia Pty Ltd.
FAU - Han, Min Seok
AU  - Han MS
AD  - Department of Internal Medicine, Institute of Gastroenterology, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Lee, Hyuk
AU  - Lee H
FAU - Jo, Jung Hyun
AU  - Jo JH
FAU - Cho, In Rae
AU  - Cho IR
FAU - Park, Jun Chul
AU  - Park JC
FAU - Shin, Sung Kwan
AU  - Shin SK
FAU - Lee, Sang Kil
AU  - Lee SK
FAU - Lee, Yong Chan
AU  - Lee YC
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Deglutition Disorders/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Manometry
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Sensation
EDAT- 2013/02/22 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/02/22 06:00
PHST- 2013/01/19 00:00 [accepted]
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1111/jgh.12136 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2013 Jun;28(6):954-62. doi: 10.1111/jgh.12136.