PMID- 23426124
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20171116
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 37
IP  - 4
DP  - 2013 Apr
TI  - EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common 
      feature of hyalinizing clear cell carcinoma.
PG  - 571-8
LID - 10.1097/PAS.0b013e3182772a15 [doi]
AB  - The Ewing sarcoma breakpoint region 1 (EWSR1) is translocated in many sarcomas. 
      Recently, its rearrangement has been described in salivary gland hyalinizing 
      clear cell carcinomas (HCCCs) and in a subset of soft tissue myoepitheliomas. 
      This study examines the presence of the EWSR1 rearrangement in a variety of 
      salivary gland lesions including classic myoepitheliomas and HCCCs. Using a 
      tissue microarray and whole-mount sections, fluorescence in situ hybridization 
      (FISH) was performed on a variety of salivary gland lesions including HCCCs. The 
      EWSR1 rearrangement was detected in 87% of HCCCs (13 of 15); all other salivary 
      gland lesions including classic myoepitheliomas had intact EWSR1. Patients with 
      HCCCs with rearranged EWSR1 included 1 man, 10 women, and 2 of unknown sex. Ages 
      ranged from 35 to 83 years; the tumor size ranged from 0.8 to 5.5 cm, and the 
      involved locations included: palate (2), base of the tongue (2), mandible (2), 
      submandibular gland (2), lip (1), floor of the mouth (1), sublingual gland (1), 
      inner cheek (1), and nasopharynx (1). All HCCCs were composed of sheets and nests 
      of monotonous cells with clear cytoplasm within a hyalinized stroma. All tested 
      cases were immunoreactive with antibodies to p63 and were nonreactive with 
      antibodies to more conventional myoepithelial antigens (e.g., smooth muscle actin 
      and S100 protein). These findings show that the EWSR1 rearrangement is almost a 
      defining feature of HCCCs and also confirm that classic salivary gland 
      myoepitheliomas are distinct from these tumors and do not share a pathogenetic 
      relationship with their soft tissue counterparts.
FAU - Shah, Akeesha A
AU  - Shah AA
AD  - Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA.
FAU - LeGallo, Robin D
AU  - LeGallo RD
FAU - van Zante, Annemieke
AU  - van Zante A
FAU - Frierson, Henry F Jr
AU  - Frierson HF Jr
FAU - Mills, Stacey E
AU  - Mills SE
FAU - Berean, Kenneth W
AU  - Berean KW
FAU - Mentrikoski, Mark J
AU  - Mentrikoski MJ
FAU - Stelow, Edward B
AU  - Stelow EB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adenocarcinoma, Clear Cell/*genetics/metabolism/secondary
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Calmodulin-Binding Proteins/*genetics
MH  - Combined Modality Therapy
MH  - DNA, Neoplasm/analysis
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - Hyalin/metabolism
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Myoepithelioma/*genetics/metabolism/secondary
MH  - RNA-Binding Protein EWS
MH  - RNA-Binding Proteins/*genetics
MH  - Salivary Gland Neoplasms/*genetics/metabolism/pathology
EDAT- 2013/02/22 06:00
MHDA- 2013/05/08 06:00
CRDT- 2013/02/22 06:00
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - 10.1097/PAS.0b013e3182772a15 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2013 Apr;37(4):571-8. doi: 10.1097/PAS.0b013e3182772a15.