PMID- 23426439
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20161214
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 28
IP  - 6
DP  - 2013 Jun
TI  - Review of renal carcinoma with t(6;11)(p21;q12) with focus on clinical and 
      pathobiological aspects.
PG  - 685-90
LID - 10.14670/HH-28.685 [doi]
AB  - Recently, a new category of MiTF/TFE family translocation carcinomas of the 
      kidney has been proposed. This category includes Xp11.2 renal cell carcinoma 
      (RCC) and the t(6;11) RCC. These tumors share clinical, morphological, 
      immunohistochemical and molecular genetic features. In this article, we review 
      t(6;11) RCC. This tumor predominantly affects children and young adults. 
      Macroscopically, the tumor generally forms a well circumscribed mass. Satellite 
      nodules may be observed. Histologically, the tumor comprises large cells and 
      small cells surrounded by basement membrane material. Immunohistochemically, 
      tumor cells show nuclear immunolabeling for TFEB and usually express Cathepsin-K 
      in the cytoplasm. Karyotyping detects the rearrangement between chromosome 6p21 
      and chromosome 11q12. Alpha-TFEB fusion can be detected by reverse transcriptase 
      polymerase chain reaction (RT-PCR) or fluorescence in situ hybridization (FISH). 
      Most cases affecting children and young adults seem to be indolent, but some 
      adult cases have presented with metastasis or caused death. As previously 
      reported cases remain limited to date, further examination in a large scale study 
      will be needed in order to elucidate clinical behavior and molecular 
      characteristics.
FAU - Kuroda, Naoto
AU  - Kuroda N
AD  - Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan. 
      kurochankochi@yahoo.co.jp
FAU - Tanaka, Azusa
AU  - Tanaka A
FAU - Sasaki, Naomi
AU  - Sasaki N
FAU - Ishihara, Akira
AU  - Ishihara A
FAU - Matsuura, Keiko
AU  - Matsuura K
FAU - Moriyama, Masatsugu
AU  - Moriyama M
FAU - Nagashima, Yoji
AU  - Nagashima Y
FAU - Inoue, Keiji
AU  - Inoue K
FAU - Petersson, Fredrik
AU  - Petersson F
FAU - Martignoni, Guido
AU  - Martignoni G
FAU - Michal, Michal
AU  - Michal M
FAU - Hes, Ondrej
AU  - Hes O
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130221
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (TFEB protein, human)
RN  - EC 3.4.22.38 (Cathepsin K)
SB  - IM
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics
MH  - Carcinoma, Renal Cell/genetics/metabolism/*pathology
MH  - Cathepsin K/metabolism
MH  - Cell Nucleus/metabolism/pathology
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 6
MH  - Gene Fusion
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/genetics/metabolism/*pathology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Translocation, Genetic
EDAT- 2013/02/22 06:00
MHDA- 2013/11/20 06:00
CRDT- 2013/02/22 06:00
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - HH-11-295 [pii]
AID - 10.14670/HH-28.685 [doi]
PST - ppublish
SO  - Histol Histopathol. 2013 Jun;28(6):685-90. doi: 10.14670/HH-28.685. Epub 2013 Feb 
      21.