PMID- 23426796
OWN - NLM
STAT- MEDLINE
DCOM- 20141125
LR  - 20211021
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 35
IP  - 4
DP  - 2014 Apr
TI  - Network analysis of auditory hallucinations in nonpsychotic individuals.
PG  - 1436-45
LID - 10.1002/hbm.22264 [doi]
AB  - BACKGROUND: Auditory verbal hallucinations (AVH) are a cardinal feature of 
      schizophrenia and can severely disrupt behavior and decrease quality of life. 
      Identification of areas with high functional connectivity (so-called hub regions) 
      that are associated with the predisposition to hallucinate may provide potential 
      targets for neuromodulation in the treatment of AVH. METHODS: Resting-state fMRI 
      scans during which no hallucinations had occurred were acquired from 29 
      nonpsychotic individuals with AVH and 29 matched controls. These nonpsychotic 
      individuals with AVH provide the opportunity to study AVH without several 
      confounds associated with schizophrenia, such as antipsychotic medication use and 
      other symptoms related to the illness. Hub regions were identified by assessing 
      weighted connectivity strength and betweenness centrality across groups using a 
      permutation analysis. RESULTS: Nonpsychotic individuals with AVH exhibited 
      increased functioning as hub regions in the temporal cortices and the posterior 
      cingulate/precuneus, which is an important area in the default mode network 
      (DMN), compared to the nonhallucinating controls. In addition, the right inferior 
      temporal gyrus, left paracentral lobule and right amygdala were less important as 
      a hub region in the AVH group. CONCLUSIONS: These results suggest that the 
      predisposition to hallucinate may be related to aberrant functioning of the DMN 
      and the auditory cortices.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - van Lutterveld, Remko
AU  - van Lutterveld R
AD  - Department of Psychiatry, University Medical Center, Utrecht, the Netherlands and 
      Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
FAU - Diederen, Kelly M J
AU  - Diederen KM
FAU - Otte, Willem M
AU  - Otte WM
FAU - Sommer, Iris E
AU  - Sommer IE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130221
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adult
MH  - Artifacts
MH  - Brain/*physiopathology
MH  - Brain Mapping/methods
MH  - Female
MH  - Hallucinations/*physiopathology
MH  - Head
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Movement
MH  - Rest/physiology
MH  - Signal Processing, Computer-Assisted
MH  - Speech Perception/*physiology
PMC - PMC6869060
OTO - NOTNLM
OT  - auditory hallucination
OT  - betweenness centrality
OT  - default mode network
OT  - degree
OT  - fMRI
OT  - graph theory
OT  - hub
OT  - psychosis
OT  - resting state
OT  - schizophrenia
EDAT- 2013/02/22 06:00
MHDA- 2014/12/15 06:00
PMCR- 2013/02/21
CRDT- 2013/02/22 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/12/11 00:00 [revised]
PHST- 2013/01/03 00:00 [accepted]
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2013/02/21 00:00 [pmc-release]
AID - HBM22264 [pii]
AID - 10.1002/hbm.22264 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2014 Apr;35(4):1436-45. doi: 10.1002/hbm.22264. Epub 2013 Feb 21.