PMID- 23426871
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20161125
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Linking)
VI  - 31
IP  - 4
DP  - 2013 Apr
TI  - Piceatannol inhibits mast cell-mediated allergic inflammation.
PG  - 951-8
LID - 10.3892/ijmm.2013.1283 [doi]
AB  - Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is 
      found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, 
      antiplatelet and antiproliferative activity. In the present study, the 
      anti-allergic and anti-inflammatory mechanisms of PIC were investigated by 
      examining the effects of PIC on pro‑inflammatory cytokine release and 
      phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in 
      a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced 
      systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC 
      reduced the immunoglobulin E (IgE)-mediated local allergic reaction and 
      attenuated histamine release from rat peritoneal mast cells. Histamine and 
      beta-hexosaminidase release was markedly decreased dose-dependently by PIC treatment 
      in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA 
      expression and the release of the pro‑inflammatory cytokines, tumor necrosis 
      factor-alpha and interleukin-8. MAP kinase phosphorylation was also strongly 
      decreased dose-dependently following PIC treatment. PIC regulated the production 
      of cytokines and histamine in phorbol 12-myristate 13-acetate plus 
      A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and 
      may be a useful therapeutic agent for allergic diseases.
FAU - Ko, Yu-Jin
AU  - Ko YJ
AD  - Division of Applied Life Sciences (BK 21 Program), Institute of Agriculture and 
      Life Sciences, Gyeongsang National University, Jinju 660-701, Republic of Korea.
FAU - Kim, Hui-Hun
AU  - Kim HH
FAU - Kim, Eun-Jung
AU  - Kim EJ
FAU - Katakura, Yoshinori
AU  - Katakura Y
FAU - Lee, Won-Sup
AU  - Lee WS
FAU - Kim, Gon-Sup
AU  - Kim GS
FAU - Ryu, Chung-Ho
AU  - Ryu CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130221
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Stilbenes)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 6KS3LS0D4F (3,3',4,5'-tetrahydroxystilbene)
RN  - 820484N8I3 (Histamine)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Anaphylaxis/chemically induced
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/*pharmacology
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Cytokines/analysis/genetics/metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Histamine/metabolism
MH  - Humans
MH  - Male
MH  - *Mast Cells/drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Signal Transduction/*drug effects
MH  - Stilbenes/chemistry/*pharmacology
MH  - beta-N-Acetylhexosaminidases/metabolism
MH  - p-Methoxy-N-methylphenethylamine/toxicity
EDAT- 2013/02/22 06:00
MHDA- 2014/04/25 06:00
CRDT- 2013/02/22 06:00
PHST- 2012/11/23 00:00 [received]
PHST- 2013/01/15 00:00 [accepted]
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - 10.3892/ijmm.2013.1283 [doi]
PST - ppublish
SO  - Int J Mol Med. 2013 Apr;31(4):951-8. doi: 10.3892/ijmm.2013.1283. Epub 2013 Feb 
      21.