PMID- 23426977
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20181202
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 93
IP  - 12
DP  - 2013 Sep
TI  - Inhibitory effect of unicellular green algae (Chlorella vulgaris) water extract 
      on allergic immune response.
PG  - 3133-6
LID - 10.1002/jsfa.6114 [doi]
AB  - BACKGROUND: Chlorella is used as a functional food in East Asia and has been 
      shown to enhance immune system function. However, there has been no direct 
      evidence of the suppressive effect of a hot water extract of Chlorella vulgaris 
      (CVE) on histamine-mediated allergic responses. RESULTS: The antihistamine 
      activity of CVE was analysed using rat peritoneal mast cells (RPMCs) stimulated 
      by compound 48/80. For in vivo verification, ovalbumin (OVA)-immunised BALB/c 
      mice were treated with CVE orally. Serum immunoglobulin E (IgE) levels and 
      splenocyte cytokine levels were determined by enzyme-linked immunosorbent assay 
      (ELISA). CVE prevented histamine release through degranulation of mast cells by 
      blocking the uptake of extracellular Ca(2)(+) into RPMCs. Moreover, CVE 
      administration inhibited serum IgE overproduction by OVA via induction of T 
      helper 1 (Th1) skewing that was dependent on interferon-gamma (IFN-gamma) and interleukin 
      12 (IL-12) secretion. CONCLUSION: The results of this study clearly demonstrate 
      that CVE acts as an antiallergic dietary agent by suppressing histamine release 
      via its enhancive effect on Th1-related responses.
CI  - (c) 2013 Society of Chemical Industry.
FAU - Bae, Min-Jung
AU  - Bae MJ
AD  - Division of Metabolism and Functionality Research, Korea Food Research Institute, 
      1201-62, Anyangpangyo-ro, Bundang-gu, Seognam-si, Kyeonggi-do, 463-746, Republic 
      of Korea.
FAU - Shin, Hee Soon
AU  - Shin HS
FAU - Chai, Ok Hee
AU  - Chai OH
FAU - Han, Jae-Gab
AU  - Han JG
FAU - Shon, Dong-Hwa
AU  - Shon DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130405
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Histamine Antagonists)
RN  - 0 (Plant Extracts)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/metabolism/*therapeutic use
MH  - Basophil Degranulation Test
MH  - Calcium Signaling
MH  - Cells, Cultured
MH  - Chlorella vulgaris/*chemistry
MH  - *Dietary Supplements
MH  - Disease Models, Animal
MH  - Female
MH  - Histamine Antagonists/metabolism/*therapeutic use
MH  - Histamine Release
MH  - Hypersensitivity/immunology/metabolism/pathology/*prevention & control
MH  - Interferon-gamma Release Tests
MH  - Interleukin-12/metabolism
MH  - Mast Cells/cytology/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/metabolism/*therapeutic use
MH  - Rats
MH  - Th1 Cells/immunology/metabolism/pathology
OTO - NOTNLM
OT  - Chlorella vulgaris water extract (CVE)
OT  - IgE
OT  - Th1
OT  - histamine
OT  - mast cells
EDAT- 2013/02/22 06:00
MHDA- 2014/03/04 06:00
CRDT- 2013/02/22 06:00
PHST- 2013/01/10 00:00 [received]
PHST- 2013/02/06 00:00 [revised]
PHST- 2013/02/20 00:00 [accepted]
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - 10.1002/jsfa.6114 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2013 Sep;93(12):3133-6. doi: 10.1002/jsfa.6114. Epub 2013 Apr 
      5.