PMID- 23428874
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20211021
IS  - 1938-1964 (Electronic)
IS  - 1938-1956 (Print)
IS  - 1938-1964 (Linking)
VI  - 4
IP  - 1
DP  - 2013 Jan-Mar
TI  - Haploidentical hematopoietic stem cell transplantation without in vitro 
      T-cell-depletion for the treatment of hematologic diseases.
PG  - 26-8
LID - 10.4161/chim.24070 [doi]
AB  - Haploidentical hematopoietic stem cell transplantation (HSCT) has been accepted 
      worldwide as an alternative treatment for patients with hematologic diseases who 
      do not have a human leukocyte antigen (HLA) identical sibling donor or who 
      require urgent transplantation. The results from our nine-year experience showed 
      that granulocyte colony-stimulating factor (G-CSF) primed bone marrow (G-BM) 
      combined with peripheral blood grafts (G-PB) from haploidentical donors, without 
      in vitro T cell depletion (TCD), is a reliable source of stem cells for 
      transplantation to cure acute leukemia and chronic myeloid leukemia. Recent 
      findings confirmed that unmanipulated haploidentical HSCT is a promising protocol 
      that can be successfully extended to treat intermediate and high-risk 
      myelodysplastic syndrome and severe aplastic anemia. Recent observations suggest 
      the association of improved immune recovery with better transplant outcomes after 
      haploidentical HSCT. Chronic graft-vs.-host-disease severity strongly correlates 
      with negative impacts on patients' health-related quality of life, suggesting 
      that it should be successfully controlled.
FAU - Huang, Xiao-Jun
AU  - Huang XJ
AD  - Peking University People's Hospital, Peking University Institute of Hematology, 
      Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, 
      Peking-Tsinghua Center for Life Sciences, Beijing, China. 
      huangxiaojun@bjmu.edu.cn
LA  - eng
PT  - Journal Article
DEP - 20130101
PL  - United States
TA  - Chimerism
JT  - Chimerism
JID - 101540510
RN  - 0 (HLA Antigens)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Graft vs Host Disease/immunology/pathology
MH  - Granulocyte Colony-Stimulating Factor/immunology
MH  - HLA Antigens/*genetics/immunology
MH  - Haplotypes/*genetics
MH  - Hematologic Diseases/*therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility/genetics/immunology
MH  - Humans
MH  - Quality of Life
MH  - *T-Lymphocytes/immunology
PMC - PMC3654735
OTO - NOTNLM
OT  - HLA
OT  - allogeneic
OT  - haploidentical
OT  - hematopoietic stem cell transplantation
OT  - mismatched
EDAT- 2013/02/23 06:00
MHDA- 2014/01/01 06:00
PMCR- 2014/01/01
CRDT- 2013/02/23 06:00
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 24070 [pii]
AID - 2013CHIMERISM0112R [pii]
AID - 10.4161/chim.24070 [doi]
PST - ppublish
SO  - Chimerism. 2013 Jan-Mar;4(1):26-8. doi: 10.4161/chim.24070. Epub 2013 Jan 1.